嗜酸性粒细胞阳离子型核糖核酸酶4/嗜酸性粒细胞源神经毒素抗体

英文名称    RNASE2    

中文名称    嗜酸性粒细胞阳离子型核糖核酸酶4/嗜酸性粒细胞源神经毒素抗体    

别    名    RNASE2; EDN; RNS2; RNAS2_HUMAN; Non-secretory ribonuclease; Eosinophil-derived neurotoxin;; RNase UpI-2; Ribonuclease 2; RNase 2; Ribonuclease US; Ear4; EC=3.1.27.5; EDN; Eosinophil cationic type ribonuclease 4; MR 4; Non secretory ribonuclease; R14; R15; R5; Ribonuclease 2; Ribonuclease RNase A family 2 (liver eosinophil derived neurotoxin); Ribonuclease US; RNase 2; RNase UpI 2.    

嗜酸性粒细胞阳离子型核糖核酸酶4/嗜酸性粒细胞源神经毒素抗体          

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  免疫学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    14kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RNASE2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

嗜酸性粒细胞阳离子型核糖核酸酶4/嗜酸性粒细胞源神经毒素抗体  产品介绍    background:
Human and animal eosinophils contain a powerful neurotoxin that causes selective neuronal and axonal damage to white matter of cerebellum and spinal cord of experimental animals when injected intrathecally. This reaction is termed the "Gordon phenomenon." We purified the eosinophil-derived neurotoxin from eosinophil-rich leukocyte suspensions or eosinophil granules from four patients with various hypereosinophilic syndromes. A single protein with an average molecular weight of 18,400 was isolated by sequential chromatography on Sephadex G-50 columns and analyzed by sodium dodecyl sulfate/polyacrylamide gel electrophoresis of column fractions. The purified eosinophil-derived neurotoxin from the cells of these patients retained the potent neurotoxic activity of the crude eosinophil or eosinophil granule extracts in experimental animals. These animals developed the syndrome of stiffness and ataxia progressing to severe paralysis characteristic of the Gordon phenomenon. Histologic examination of the brains of animals injected with purified eosinophil-derived neurotoxin confirmed the characteristic widespread loss of Purkinje cells and severe spongiform vacuolation in the white matter of cerebellum, brain stem, and spinal cord. We have established the location of eosinophil-derived neurotoxin in the eosinophil granule and have shown that it is distinct from several other eosinophil proteins, the granule major basic protein, and the Charcot-Leyden crystal protein (lysophospholipase).

Subcellular Location:
Lysosome (Probable). Cytoplasmic granule. Matrix of eosinophil's large specific granule.

Similarity:
Belongs to the pancreatic ribonuclease family.

Gene ID:
6036

Database links:

Entrez Gene: 6036 Human

Omim: 131410 Human

SwissProt: P10153 Human

Unigene: 728 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

嗜酸性粒细胞阳离子型核糖核酸酶4/嗜酸性粒细胞源神经毒素抗体  

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二、标记一抗

编  号 名  称

三、二抗

编  号 名  称

hz-0373R Dog IgM  兔抗犬IgM抗体

hz-0326Gs Goat anti-Bovine IgG whole serum  羊抗牛IgG抗血清

hz-0296Gs Goat anti-Mouse IgG whole serum  羊抗小鼠IgG抗血清

hz-0368Gs Goat anti-Mouse IgM whole serum  羊抗小鼠IgM抗血清

hz-0293Gs Goat anti-rat IgG whole serum  羊抗大鼠IgG抗血清

hz-0358Gs Goat anti-Gpig IgG whole serum  羊抗豚鼠IgG抗血清

hz-0295Gs Goat anti-Rabbit IgG whole serum  羊抗兔IgG抗血清

hz-0297Gs Goat anti-human IgG whole serum  羊抗人IgG抗血清

hz-0345Gs Goat anti-human IgM whole serum  羊抗人IgM抗血清

hz-0310Gs Goat anti-Chicken IgG whole serum  羊抗鸡IgG抗血清

hz-0297Ms Mouse anti-human IgG ascites  小鼠抗人IgG腹水

hz-0345Ms Mouse anti-human IgM ascites  小鼠抗人IgM腹水

hz-0294Ms Mouse anti-Goat IgG ascites  小鼠抗羊IgG腹水

hz-0295Ms Mouse anti-rabbit IgG ascites  小鼠抗兔IgG腹水

hz-0293Ms Mouse anti-rat IgG ascites  小鼠抗大鼠IgG腹水

hz-0326Ms Mouse anti-Bovine IgG ascites  小鼠抗牛IgG腹水

hz-0312Rs Rabbit anti-Avidin whole serum  兔抗亲和素抗血清

hz-0311Rs Rabbit anti-Biotin whole serum  兔抗生物素抗血清

hz-0326Rs Rabbit anti-Bovine IgG whole serum  兔抗牛IgG抗血清

hz-0327Rs Rabbit anti-Bovine IgM whole serum  兔抗牛IgM抗血清

hz-0310Rs Rabbit anti-chicken IgG whole serum  兔抗鸡IgG抗血清

hz-0314Rs Rabbit anti-chicken IgM whole serum  兔抗鸡IgM抗血清