RSPO4蛋白抗体

英文名称    RSPO4    

中文名称    RSPO4蛋白抗体    

别    名    C20orf182; CRISTIN4; hRspo4; R-spondin family, member 4; R-spondin-4; Roof plate-specific spondin-4; RSPO4; RSPO4_HUMAN.    

RSPO4蛋白抗体    

说 明 书    0.2ml      

研究领域    细胞生物  发育生物学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig, Cow, Horse, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    24kDa    

细胞定位    分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RSPO4    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

RSPO4蛋白抗体产品介绍    background:
This gene encodes a member of the R-spondin family of proteins that share a common domain organization consisting of a signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated with anonychia congenital. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009]

Function:
Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors.

Subcellular Location:
Secreted.

Post-translational modifications:
Tyr-112 may be phosphorylated; however as this position is probably extracellular, the vivo relevance is not proven.

DISEASE:
Defects in RSPO4 are the cause of anonychia congenita (ANONC) [MIM:206800]. A rare condition characterized by the absence or severe hypoplasia of all fingernails and toenails without significant bone anomalies.

Similarity:
Belongs to the R-spondin family.
Contains 1 FU (furin-like) repeat.
Contains 1 TSP type-1 domain.

Gene ID:
343637

Database links:

Entrez Gene: 343637 Human

Entrez Gene: 228770 Mouse

Entrez Gene: 499918 Rat

Omim: 610573 Human

SwissProt: Q2I0M5 Human

SwissProt: Q8BJ73 Mouse

Unigene: 444980 Human

Unigene: 159868 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

RSPO4蛋白抗体

hz-2029R Morphine  吗啡抗体

hz-2129R Morphine  吗啡抗体

hz-5087R Monoacylglycerol Lipase  单酰甘油脂肪酶抗体

hz-3590R Torc2/Crtc2  CREB转录共激活因子TORC2抗体

hz-3415R Phospho-Torc2/Crtc2(Ser171)  磷酸化CREB转录共激活因子TORC2抗体

hzm-2129M Morphine(2F11)  吗啡单克隆抗体

hzm-2069M Ketamine(4E2)  氯胺酮抗体

hz-4128R MAP4  微管相关蛋白4抗体

hz-4134R MAP4K1  造血祖细胞激酶1抗体

hz-5494R phospho-MAP4K1(Ser171)  磷酸化造血祖细胞激酶抗体

hzm-2070M Amphetamine(2A3F6)  苯丙胺单克隆抗体（安非他明）

hzm-2117M Cocaine(C2F1)  可卡因单克隆抗体

hz-5438R phospho-MAP4(Ser941)  磷酸化微管相关蛋白4抗体

hz-5439R phospho-MAP4(Ser1046)  磷酸化微管相关蛋白4抗体

hz-5468R phospho-MAP4(Ser1073)  磷酸化微管相关蛋白4抗体

hz-4133R MAP4K4  丝裂原活化蛋白激酶MAP4K4抗体

hz-5491R phospho-MAP4K4(Ser629)  磷酸化丝裂原活化蛋白激酶MAP4K4抗体

hz-5492R phospho-MAP4K4(Ser631)  磷酸化丝裂原活化蛋白激酶MAP4K4抗体

hz-5493R phospho-MAP4K4(Ser801)  磷酸化丝裂原活化蛋白激酶MAP4K4抗体

hz-1041R MEK1/2(MAPKK1)  丝裂原活化蛋白激酶激酶1抗体

hz-0223R MEK2/MAPKK2  丝裂原活化蛋白激酶激酶2抗体

hz-2908R MAPKAP Kinase 2  丝裂原活化蛋白激酶活化的蛋白激酶2抗体

hz-3261R Phospho-MAPKAPK2 (Thr222)  磷酸化丝裂原活化蛋白激酶活化的蛋白激酶2抗体

hz-3262R Phospho-MAPKAPK2(Thr334)  磷酸化丝裂原活化蛋白激酶活化的蛋白激酶2抗体

hz-5503R Phospho-MAPKAPK2(Ser272)  磷酸化丝裂原活化蛋白激酶活化的蛋白激酶2抗体

hz-5426R phospho-MEK2(Tyr78)  磷酸化丝裂原活化蛋白激酶激酶2抗体

hz-1976R Matrilin 1  软骨基质蛋白抗体

hz-5427R phospho-MEK2(Thr394)  磷酸化丝裂原活化蛋白激酶激酶2抗体

hz-5498R phospho-MEK2(Ser226)  磷酸化丝裂原活化蛋白激酶激酶2抗体

hz-1425R MAP3K5/ASK1/MEKK5  细胞凋亡信号调节激酶1抗体

hz-3007R phospho-ASK1 (Ser966)  磷酸化细胞凋亡信号调节激酶1抗体

hz-3029R phospho-ASK1(Ser967)  磷酸化细胞凋亡信号调节激酶1抗体

hz-3031R phospho-ASK1(Thr845)  磷酸化细胞凋亡信号调节激酶1抗体

hz-5436R phospho-ASK1(Ser83)  磷酸化细胞凋亡信号调节激酶1抗体

hz-5437R phospho-ASK1(Ser1033)  磷酸化细胞凋亡信号调节激酶1抗体