信号感应增殖相关蛋白1抗体

英文名称    SPA-1    

中文名称    信号感应增殖相关蛋白1抗体    

别    名    GTPase activating protein Spa 1; GTPase-activating protein Spa-1; MGC102688; MGC17037; p130 SPA-1; p130 SPA1; Signal induced proliferation associated 1; Signal induced proliferation associated gene 1; Signal induced proliferation associated protein 1; signal-induced proliferation-associated gene 1; Signal-induced proliferation-associated protein 1; SIPA 1; Sipa-1; Sipa1; SIPA1_HUMAN; Spa1.    

信号感应增殖相关蛋白1抗体 

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  染色质和核信号  信号转导  干细胞  细胞凋亡  细胞周期蛋白  细胞表面分子  表观遗传学  G蛋白信号      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    112kDa    

细胞定位    细胞核 细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human SPA-1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

信号感应增殖相关蛋白1抗体产品介绍    background:
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.

Function:
GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state.

Subcellular Location:
Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein. Note=Mostly localized in the perinuclear membraneous region.

Tissue Specificity:
Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.

Similarity:
Contains 1 PDZ (DHR) domain.
Contains 1 Rap-GAP domain.

Gene ID:
6494

Database links:

Entrez Gene: 6494 Human

Entrez Gene: 20469 Mouse

Omim: 602180 Human

SwissProt: Q96FS4 Human

SwissProt: P46062 Mouse

Unigene: 530477 Human

Unigene: 3072 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

信号感应增殖相关蛋白1抗体

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hz-0294M-AF350 Mouse Anti-Goat IgG/Alexa Fluor 350  Alexa Fluor 350标记的小鼠抗羊IgG

hz-0294M-AF488 Mouse Anti-Goat IgG/Alexa Fluor 488  Alexa Fluor 488标记的小鼠抗羊IgG

hz-0294M-AF555 Mouse Anti-Goat IgG/Alexa Fluor 555  Alexa Fluor 555标记的小鼠抗羊IgG

hz-0294M-AF647 Mouse Anti-Goat IgG/Alexa Fluor 647  Alexa Fluor 647标记的小鼠抗羊IgG

hz-0294M-PE-hzy5.5 Mouse Anti-Goat IgG/PE-Cy5.5  PE-Cy5.5标记的小鼠抗羊IgG

hz-0294M-PE-hzy7 Mouse Anti-Goat IgG/PE-Cy7  PE-Cy7标记的小鼠抗羊IgG

hz-0294M-AP Mouse Anti-Goat IgG/AP  碱性磷酸酶（AP）标记的小鼠抗羊IgG

hz-0294M-FIThz Mouse Anti-Goat IgG/FITC  FITC标记的小鼠抗羊IgG

hz-0295M-FIThz Mouse Anti-rabbit IgG/FITC  FITC标记的小鼠抗兔IgG

hz-0295M-RBIThz Mouse Anti-rabbit IgG/RBITC  罗丹明标记的小鼠抗兔IgG

hz-0295M-Gold Mouse Anti-rabbit IgG/Gold  胶体金标记的小鼠抗兔IgG

hz-0295M-AP Mouse Anti-rabbit IgG/AP  碱性磷酸酶（AP）标记的小鼠抗兔IgG

hz-0295M-Bio Mouse Anti-rabbit IgG/Bio  生物素标记的小鼠抗兔IgG

hz-0295M-hzy3 Mouse Anti-rabbit IgG/Cy3  Cy3标记的小鼠抗兔IgG

hz-0295M-hzy5 Mouse Anti-rabbit IgG/Cy5  Cy5标记的小鼠抗兔IgG

hz-0295M-hzy5.5 Mouse Anti-rabbit IgG/Cy5.5  Cy5.5标记的小鼠抗兔IgG

hz-0295M-hzy7 Mouse Anti-rabbit IgG/Cy7  Cy7标记的小鼠抗兔IgG

hz-0295M-PE Mouse Anti-rabbit IgG/PE  PE标记的小鼠抗兔IgG

hz-0295M-PE-hzy3 Mouse Anti-rabbit IgG/PE-Cy3  PE-Cy3标记的小鼠抗兔IgG

hz-0295M-PE-hzY5 Mouse Anti-rabbit IgG/PE-CY5  PE-CY5标记的小鼠抗兔IgG

hz-0295M-APhz Mouse Anti-rabbit IgG/APC  APC标记的小鼠抗兔IgG

hz-0295M-AF555 Mouse Anti-rabbit IgG/Alexa Fluor 555  Alexa Fluor 555标记的小鼠抗兔IgG

hz-0295M-AF647 Mouse Anti-rabbit IgG/Alexa Fluor 647  Alexa Fluor 647标记的小鼠抗兔IgG

hz-0295M-PE-hzy5.5 Mouse Anti-rabbit IgG/PE-Cy5.5  PE-Cy5.5标记的小鼠抗兔IgG

hz-0295M-PE-hzy7 Mouse Anti-rabbit IgG/PE-Cy7  PE-Cy7标记的小鼠抗兔IgG

hz-0295M-AF350 Mouse Anti-rabbit IgG/Alexa Fluor 350  Alexa Fluor 350标记的小鼠抗兔IgG

hz-0295M-AF488 Mouse Anti-rabbit IgG/Alexa Fluor 488  Alexa Fluor 488标记的小鼠抗兔IgG

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