英文名称 Syndecan-1
中文名称 多配体蛋白聚糖1抗体
别 名 SDC1; SDC; SYND1; Syndecan I; SyndecanI; Syndecan-I; syndecan; Sdc1; Syndecan1, Syndecan-1; AA408134; AA409076; Sstn; syn-1; CD 138; CD138 antigen; Heparan sulfate proteoglycan fibroblast growth factor receptor; SDC 1; Syndecan1 precursor; SDC1_HUMAN.
多配体蛋白聚糖1抗体
说 明 书 0.1ml 0.2ml
研究领域 肿瘤 神经生物学 细胞膜受体 细胞粘附分子 细胞表面分子 糖蛋白 上皮细胞 内皮细胞
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
细胞定位 细胞膜 分泌型蛋白
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD138
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
多配体蛋白聚糖1抗体 产品介绍 background:
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008].
Function:
Cell surface proteoglycan that bears both heparin sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.
Subunit:
Interacts with CDCP1.
Subcellular Location:
Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form.
Post-translational modifications:
Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
Similarity:
Belongs to the syndecan proteoglycan family.
Gene ID:
6382
Database links:
Entrez Gene: 6382 Human
Entrez Gene: 20969 Mouse
Entrez Gene: 25216 Rat
Omim: 186355 Human
SwissProt: P18827 Human
SwissProt: P18828 Mouse
SwissProt: P26260 Rat
Unigene: 224607 Human
Unigene: 665958 Human
Unigene: 2580 Mouse
Unigene: 11176 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
多配体蛋白聚糖1抗体
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