神经突触前膜胞内蛋白18抗体

英文名称    STXBP1/Munc18-1    

中文名称    神经突触前膜胞内蛋白18抗体    

别    名    Munc 18 1; Munc 18a; NSec1; p67; Rb sec1; STXBP1; Syntaxin binding protein 1; Unc 18 homolog; Unc 18A; Unc18 1; STXB1_HUMAN; Syntaxin-binding protein 1; MUNC18-1; N-Sec1; Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A; Unc-18A; p67.    

神经突触前膜胞内蛋白18抗体         

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  免疫学  神经生物学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    68kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Munc18 (2-45aa)    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

神经突触前膜胞内蛋白18抗体 产品介绍    background:
This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]

Function:
May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.

Subunit:
Binds SYTL4. Interacts with STX1A.

Subcellular Location:
Cytoplasm. Membrane; Peripheral membrane protein.

Tissue Specificity:
Brain and spinal cord. Highly enriched in axons.

DISEASE:
Defects in STXBP1 are the cause of epileptic encephalopathy early infantile type 4 (EIEE4) [MIM:612164]. Affected individuals have neonatal or infantile onset of seizures, suppression-burst pattern on EEG, profound mental retardation, and MRI evidence of hypomyelination.

Similarity:
Belongs to the STXBP/unc-18/SEC1 family.

Database links:

Entrez Gene: 6812 Human

Entrez Gene: 20910 Mouse

Entrez Gene: 25558 Rat

Entrez Gene: 404293 Chicken

Omim: 602926 Human

SwissProt: Q6R748 Chicken

SwissProt: P61764 Human

SwissProt: O08599 Mouse

SwissProt: P61765 Rat

Unigene: 288229 Human

Unigene: 278865 Mouse

Unigene: 80843 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

神经突触前膜胞内蛋白18抗体 

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hz-1184R TRAF6  肿瘤坏死因子受体相关因子6抗体

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hz-4041R Transaldolase 1  转醛醇酶抗体

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hz-2722R TRhz1  髓系细胞触发受体1抗体

hz-2723R TRhz2  髓系细胞触发受体2抗体

hz-2724R TRhzL1/TLT1  髓系细胞触发受体样转录因子1抗体

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hz-5907R Ferritin  铁蛋白抗体

hz-2052R Transferrin  转铁蛋白抗体

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hz-1922R TRF2  端粒结合蛋白2抗体

hz-1909R Telomerase Binding Protein, P23  端粒酶结合蛋白P23抗体

hz-4020R phospho-p23 (Ser113)  磷酸化端粒酶结合蛋白P23抗体

hz-0964R TRIM32  TRIM32抗体

hz-0193R TrK A/NTRK1  酪氨酸激酶A抗体

hz-3456R Phospho-TrkA (Tyr490)/TrkB (Tyr516)  磷酸化酪氨酸激酶A抗体

hz-3457R Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707)  磷酸化酪氨酸激酶A抗体

hz-3732R Phospho-TrkA (Tyr785)/TrkB (Tyr816)  磷酸化酪氨酸激酶A抗体

hz-0192R Trk A/B/C  酪氨酸激酶A/B/C抗体

hz-0175R Trk B/NTRK2  酪氨酸激酶B抗体

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