固醇携带蛋白2抗体

英文名称    SCP2    

中文名称    固醇携带蛋白2抗体    

别    名    DKFZp686C12188; DKFZp686D11188; NLTP; Nonspecific lipid transfer protein; NSL TP; OTTHUMP00000010488; Propanoyl CoA C acyltransferase; SCP 2; SCP chi; SCP X; SCP2; SCPchi; SCPX; Sterol carrier protein 2; Sterol carrier protein X; NLTP_HUMAN.    

固醇携带蛋白2抗体

说 明 书    0.1ml  0.2ml      

研究领域    心血管  细胞生物  免疫学  染色质和核信号  细胞周期蛋白  合成与降解  细胞分化  细胞骨架  线粒体      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Cow, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    59kDa    

细胞定位    细胞核 线粒体    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human SCP2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

固醇携带蛋白2抗体产品介绍    background:
This gene encodes two proteins: sterol carrier protein X(SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. [provided by RefSeq, Aug 2010]

Function:
Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.

Subunit:
Interacts with PEX5.

Subcellular Location:
Cytoplasm. Mitochondrion. Note=Cytoplasmic in the liver and also associated with mitochondria especially in steroidogenic tissues.
Isoform SCPx: Peroxisome. Note=Interaction with PEX5 is essential for peroxisomal import. 
Isoform SCP2: Mitochondrion (Probable). 

Tissue Specificity:
Liver, fibroblasts, and placenta.

DISEASE:
Leukoencephalopathy, with dystonia and motor neuropathy (LDMN) [MIM:613724]: A syndrome characterized by leukoencephalopathy, dystonic head tremor, spasmodic torticollis and reduced tendon reflexes in lower extremities. Additional features include hyposmia, pathologic saccadic eye movements, a slight hypoacusis, accumulation of branched-chain pristanic acid in plasma, and the presence of abnormal bile alcohol glucuronides in urine. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
In the N-terminal section; belongs to the thiolase family. 
Contains 1 SCP2 domain.

Gene ID:
6342

Database links:

Entrez Gene: 6342 Human

Entrez Gene: 20280 Mouse

Entrez Gene: 25541 Rat

Omim: 184755 Human

SwissProt: P22307 Human

SwissProt: P32020 Mouse

SwissProt: P11915 Rat

Unigene: 476365 Human

Unigene: 379011 Mouse

Unigene: 31887 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.     

固醇携带蛋白2抗体

hz-5690R phospho-Rab24(Ser95)  磷酸化ras基因相关蛋白Rab24抗体

hz-5691R phospho-Rab24(Tyr17)  磷酸化ras基因相关蛋白Rab24抗体

hz-1221R Rad51  Rad51抗体

hz-1878R Rad52  Rad52抗体

hz-5684R phospho-RAD51(Tyr315)  磷酸化Rad51抗体

hz-2186R RAD51C  乳腺癌和卵巢癌易感基因RAD51C抗体

hz-3791R RAE1  mRNA结合蛋白抗体

hz-3808R Radixin  根蛋白抗体

hz-3559R Raptor  mTOR相关调控蛋白抗体

hz-3381R Phospho-Raptor (Ser792)  磷酸化mTOR相关调控蛋白抗体

hz-1504R RAP1A  抗Rap1A抗体

hz-5106R ALDH1  乙醛脱氢酶1型抗体

hz-5110R ALDH2/ALDHI  乙醛脱氢酶2抗体

hz-3676R RALDH2  视黄醛脱氢酶2型抗体

hz-5709R ALDH1L1  乙醛脱氢酶1蛋白家族L1抗体

hz-1731R phospho-c-Raf(Ser338/Tyr340)  磷酸化原癌基因c-Raf抗体

hz-3372R phospho-c-Raf (Ser289)  磷酸化原癌基因c-Raf抗体

hz-3375R phospho-c-Raf(Ser259)  磷酸化原癌基因c-Raf抗体

hz-3376R phospho-c-Raf(Ser296)  磷酸化原癌基因c-Raf抗体

hz-3377R phospho-c-Raf(Ser338)  磷酸化原癌基因c-Raf抗体

hz-5645R phospho-c-Raf(Ser301)  磷酸化原癌基因c-Raf抗体

hz-5646R phospho-c-Raf(Ser462)  磷酸化原癌基因c-Raf抗体

hz-5647R phospho-c-Raf(Ser494)  磷酸化原癌基因c-Raf抗体

hz-5648R phospho-c-Raf(Ser43)  磷酸化原癌基因c-Raf抗体

hz-5649R phospho-c-Raf(Ser471)  磷酸化原癌基因c-Raf抗体

hz-5650R phospho-c-Raf(Tyr341)  磷酸化原癌基因c-Raf抗体

hz-5651R phospho-c-Raf(Thr269)  磷酸化原癌基因c-Raf抗体

hz-3560R RASGRF1  Ras特异性鸟嘌呤核苷酸释放因子1

hz-3382R Phospho-RasGRF1(Ser916)  磷酸化Ras特异性鸟嘌呤核苷酸释放因子1

hz-5652R phospho-c-Raf(Ser339)  磷酸化原癌基因c-Raf抗体

hz-5683R Phospho-RASGRF1(Ser929)  磷酸化Ras特异性鸟嘌呤核苷酸释放因子1

hz-0251R RAR α  维甲酸受体-α 抗体

hz-0516R RAR Beta  维甲酸受体β抗体

hz-6218R RAR gamma/Retinoic Acid Receptor gamma  维甲酸受体γ抗体

hz-1234R RASSF1A  Ras相关区域家族1A抗体

hz-5706R RASSF4  Ras相关区域家族蛋白4抗体

hz-2939R RASSF2  Ras相关结构域蛋白质2抗体

hz-6089R RASSF8  RAS家族关联结构域蛋白8抗体

hz-1515R Pan-ras  Pan ras抗体

hz-3545R RCC1  染色体浓缩调控蛋白1抗体

hz-3360R Phospho-RCC1 (Ser11)  磷酸化染色体浓缩调控蛋白1抗体

hz-3558R phospho-Rb(Ser249)  视网膜母细胞瘤相关蛋白1抗体

hz-3378R Phospho-Rb (Ser608)  磷酸化视网膜母细胞瘤相关蛋白1抗体

hz-3380R Phospho-Rb (Ser807/Ser811)  磷酸化视网膜母细胞瘤相关蛋白1抗体