锌指转录因子Slug+SNAIL抗体

英文名称    SNAIL + SLUG    

中文名称    锌指转录因子Slug+SNAIL抗体    

别    名    SNAIL+SLUG; dJ710H13.1; Protein sna; Protein snail homolog; SLUGH2; SNA; Sna protein; SNAH; SNAI1; Snail homolog 1 (Drosophila); Zinc finger protein SNAI1; SNAI1_HUMAN; Protein snail homolog 1; dJ710H13.1; SNAIL; SNAIL1; Protein sna; Neural crest transcription factor Slug; Protein snail homolog 2; Slug (chicken homolog) zinc finger protein; Slug homolog zinc finger protein; Slug zinc finger protein; SLUGH 1; SLUGH; SLUGH1; SNAI 2; SNAI2; SNAI-2; SNAI2_HUMAN; Snail 2; Snail homolog 2; Snail2; Snail-2; WS 2D; WS2D; Zinc finger protein SLUG; Zinc finger protein SNAI2.    

锌指转录因子Slug+SNAIL抗体        

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  免疫学  神经生物学  信号转导  干细胞  转录调节因子  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, Guinea Pig, Danio rerio    

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    30kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human SNAIL + SLUG (211-264aa)    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

锌指转录因子Slug+SNAIL抗体产品介绍    background:
SNAIL: The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008].
SLUG: This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008].

Function:
Involved in the epithelial to mesenchymal transition (EMT) and formation and maintenance of embryonic mesoderm. Binds to 3 E-boxes of the E-cadherin gene promoter and represses its transcription.

Subunit:
Interacts with FBXL14 and GSK3B. Interacts with BTRC; interaction occurs when it is phosphorylated on the destruction motif. Interacts (via SNAG domain) with WTIP (via LIM domains). Interacts (via SNAG domain) with LIMD1 (via LIM domains), and AJUBA (via LIM domains). Interacts with LOXL2 and LOXL3.

Subcellular Location:
Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs.

Tissue Specificity:
Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.

Post-translational modifications:
Phosphorylated by GSK3B. Once phosphorylated, it becomes a target for BTRC ubiquitination.
Ubiquitinated on Lys-98, Lys-137 and Lys-146 by FBXL14 and BTRC leading to degradation. BTRC-triggered ubiquitination requires previous GSK3B-mediated SNAI1 phosphorylation.
O-GlcNAcylation at Ser-112 is enhanced in hyperglycaemic conditions, it opposes phosphorylation by GSK3B, and stabilizes the protein.

Similarity:
Belongs to the snail C2H2-type zinc-finger protein family. 
Contains 4 C2H2-type zinc fingers.

Database links:
UniProtKB/Swiss-Prot: O95863.2 (human SNAI1)
UniProtKB/Swiss-Prot: O43623.1 (human SLUG)

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

锌指转录因子Slug+SNAIL抗体

hz-2491R CD27/TNFRSF7  CD27抗体

hz-1297R CD28  CD28抗体

hz-0878R CD144/VECD/VE Cadherin  上皮型钙粘附分子抗体

hz-4142R NPTX1  神经细胞正五聚体1抗体

hz-5527R phospho-NPTX1(Tyr344)  磷酸化神经细胞正五聚体1抗体

hz-0684R CD147/TCSF/hzmprin  细胞外基质金属蛋白酶诱导因子抗体

hz-2526R CD160/By55  NK细胞受体BY55抗体

hz-2807R CD161   CD161抗体

hz-4682R CD161c/NK1.1  CD161抗体

hz-2527R CD163/M130  CD163抗体

hz-1251R CD166  活化白细胞粘附分子抗体

hz-2419R CD158a/KIR2DL1  NK细胞抑制性受体2DL1抗体

hz-2421R CD158e  NK细胞抑制性受体3DL1抗体

hz-2642R CD158b2  NK细胞抑制性受体2DL3抗体

hz-2643R CD158  NK细胞抑制性受体2DL4抗体

hz-2644R CD158i  NK细胞抑制性受体2DS4抗体

hz-2645R CD158e  NK细胞抑制性受体3DL1抗体

hz-0671R MCK10/CD167a/DDR1  神经上皮酪氨酸激酶抗体（乳腺癌激酶10）

hz-4194R CD167b/DDR2  盘状结构域受体蛋白2抗体

hz-3845R CD168/RHAMM  透明质酸介导细胞游走受体抗体

hz-0794R CD169/sialoadhesin  唾液酸结合性免疫球蛋白样凝集素1抗体

hz-2703R CD170/Siglec-5  唾液酸结合性免疫球蛋白样凝集素5抗体

hz-1482R CD177/NB1  嗜中性粒细胞抗原CD177抗体

hz-2569R CD226/DNAM-1  CD226抗体

hz-2529R CD229/SLAMF3  CD229抗体

hz-0503R Integrin β2/CD18/LFA-1  整合素β2抗体

hz-3264R Phospho-CD18 (Ser756/Thr758/759)  磷酸化整合素β2抗体

hz-1011R CD184/CXCR4  细胞表面趋化因子受体4抗体

hz-0079R CD19  CD19抗体

hz-3065R Phospho-CD19(Tyr531)  磷酸化CD19抗体

hz-0080R CD20  CD20抗体

hz-3792R CD21/EBV receptor  2型补体受体抗体

hz-1481R CD22/BLCAM  B淋巴细胞粘附分子CD22抗体

hz-2490R CD23/Fc EpsilonR II  CD23抗体

hz-0528R CD24  CD24抗体

hz-4263R ENaCg/γENaC  上皮钠离子通道蛋白γ抗体

hz-4264R DMRT3  睾丸特异性DMRT3蛋白抗体

hz-4267R CARF/CDKN2AIP  钙反应因子抗体

hz-0577R CD25/IL-2RA  白介素2受体a链抗体 IL-2Ra