阅读障碍相关蛋白Shootin抗体

英文名称    KIAA1598    

中文名称    阅读障碍相关蛋白Shootin抗体

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别    名    DKFZp686A0439; hypothetical protein FLJ11122; Kiaa1598; MGC40476; Putative uncharacterized protein KIAA1598; Shootin 1; Shootin-1; Shootin; SHOT1_HUMAN.    

阅读障碍相关蛋白Shootin抗体       

说 明 书    0.2ml      

研究领域    细胞生物  细胞分化      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig, Cow, Horse,     

产品应用    IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    72kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml

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免 疫 原    KLH conjugated synthetic peptide derived from human Shootin/KIAA1598    

亚    型    IgG    

纯化方法    affinity purified by Protein A

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储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

阅读障碍相关蛋白Shootin抗体产品介绍    background:
Shootin1 is a 631 amino acid protein that belongs to the shootin family. The shootin1 protein contains three coiled-coil domains, a proline-rich region and interacts with RUFY3. Shootin1 is involved in the generation of internal asymmetric signals required for neuronal polarization. The shootin1 protein acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K activity. By accumulating asymmetrically in a single neurite before polarization, shootin1 leads to axon induction for polarization, additionally the absence of shootin1 from the nascent axon's siblings by competition prevents the formation of surplus axons. Existing as seven alternatively spliced isoforms, the shootin1 gene is conserved in chimpanzee, dog, mouse, rat, chicken and zebrafish, and maps to human chromosome 10q25.3.

Function:
Involved in the generation of internal asymmetric signals required for neuronal polarization. Acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K activity. Accumulates asymmetrically in a single neurite before polarization, leading to axon induction for polarization, its absence from the nascent axon's siblings by competition preventing the formation of surplus axons.

Subunit:
Interacts with RUFY3

Subcellular Location:
Cell projection.

DISEASE:

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Similarity:
Belongs to the shootin family.

Database links:

Entrez Gene: 57698 Human

Entrez Gene: 292139 Rat

Omim: 611171 Human

SwissProt: A0MZ66 Human

SwissProt: A0MZ67 Rat

Unigene: 501140 Human

Unigene: 16095 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

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