细胞因子信号传导抑制蛋白6抗体

英文名称    SOCS6    

中文名称    细胞因子信号传导抑制蛋白6抗体    

别    名    CIS-4; CIS4; Cish4; Cytokine inducible SH2 protein 4; Cytokine-inducible SH2 protein 4; HSPC060; SOCS-4; SOCS-6; SOCS4; Socs6; SOCS6_HUMAN; SSI4; STAI4; STAT induced STAT inhibitor 4; STAT4; STATI4; Suppressor of cytokine signaling 4; Suppressor of cytokine signaling 6.    

细胞因子信号传导抑制蛋白6抗体           

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  信号转导      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    59kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human SOCS6    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

细胞因子信号传导抑制蛋白6抗体   产品介绍    background:
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008].

Function:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.

Subunit:
Interacts with RBCK1. Interacts with phosphorylated IRS4. Interacts with PIM3. Interacts with KIT (phosphorylated).

Similarity:
Contains 1 SH2 domain. 
Contains 1 SOCS box domain.

Gene ID:
9306

Database links:

Entrez Gene: 9306 Human

Entrez Gene: 54607 Mouse

Omim: 605118 Human

SwissProt: O14544 Human

SwissProt: Q9JLY0 Mouse

Unigene: 44439 Human

Unigene: 476577 Mouse

Unigene: 91920 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

细胞因子信号传导抑制蛋白6抗体   

hz-9667R DENND2C  MAP激酶激活死亡域蛋白2C抗体

hz-9668R DENND2D  MAP激酶激活死亡域蛋白2D抗体

hz-9669R DENND4C  MAP激酶激活死亡域蛋白4C抗体

hz-9670R DHFRL1  二氢叶酸还原酶样1抗体

hz-1570R APOH  载脂蛋白H抗体

hz-9671R ASH1L  ASH1蛋白抗体

hz-9672R LAS2/C18orf54  肺腺瘤易感蛋白2抗体

hz-9673R Mel18/ZNF144  锌指蛋白蛋白144抗体

hz-9674R MYLIP/Idol  低密度脂蛋白受体的诱导降解蛋白抗体

hz-9675R C18orf56  18号染色体开放阅读框56抗体

hz-9676R MIC1/C18orf8  结肠癌相关蛋白MIC1抗体

hz-9677R C19orf18  19号染色体开放阅读框18抗体

hz-9678R C19orf21  19号染色体开放阅读框21抗体

hz-9679R C19orf24  19号染色体开放阅读框24抗体

hz-9680R MFSD12/C19orf28  19号染色体开放阅读框28抗体

hz-9681R C19orf45  19号染色体开放阅读框45抗体

hz-9682R C19orf46  19号染色体开放阅读框46抗体

hz-9683R C19orf47  19号染色体开放阅读框47抗体

hz-9684R C19orf54  19号染色体开放阅读框54抗体

hz-9685R C1GALT1  N-乙酰半乳糖胺糖蛋白3、β-半乳糖转移酶1抗体

hz-9686R VGLUT2  囊泡谷氨酸转运蛋白2抗体

hz-9687R Phospho-BLNK(Tyr84)  磷酸化T淋巴细胞连接蛋白抗体

hz-9688R Phospho-BLNK(Tyr491)  磷酸化T淋巴细胞连接蛋白抗体

hz-9689R TWA1/C20orf11  20号染色体开放阅读框11抗体

hz-9690R C20ORF141  20号染色体开放阅读框141抗体

hz-9691R C20orf103  20号染色体开放阅读框103抗体

hz-9692R C20orf111  过氧化氢诱导转录蛋白1抗体

hz-9693R C20orf112  20号染色体开放阅读框112抗体

hz-9694R C20orf132  20号染色体开放阅读框132抗体

hz-9695R C20orf160  20号染色体开放阅读框160抗体

hz-9696R KIZUNA/C20orf19  20号染色体开放阅读框19抗体

hz-9697R C20orf194  20号染色体开放阅读框194抗体

hz-9698R C20orf195  20号染色体开放阅读框195抗体

hz-9699R C20orf196  20号染色体开放阅读框196抗体