信号肽复合物亚基3抗体

英文名称    SPCS3    

中文名称    信号肽复合物亚基3抗体    

别    名    DKFZp564J1864; FLJ22649; Microsomal signal peptidase 22/23 kDa subunit; Microsomal signal peptidase 23 kDa subunit; PRO3567; Signal peptidase complex subunit 3; Signal peptidase complex subunit 3 homolog (S. cerevisiae); Signal peptidase complex subunit 3 homolog; SPase 22 kDa subunit; SPase 22/23 kDa subunit; SPC22; SPC22/23; SPC3; UNQ1841; YLR066W.    

信号肽复合物亚基3抗体      

说 明 书    0.2ml      

研究领域    细胞生物  信号转导  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Guinea Pig,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    20kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human SPCS3    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

信号肽复合物亚基3抗体产品介绍    background:
SPCS3 (signal peptidase complex subunit 3), also known as SPC3, is a 180 amino acid single-pass type II membrane protein that localizes to both the microsome and the endoplasmic reticulum (ER) and belongs to the SPCS (signal peptidase complex subunit) family. Existing as a component of the microsomal signal peptidase complex which consists of five members, SPCS3 functions to remove signal peptides from proteins that are translated to the lumen of the ER. The gene encoding SPCS3 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.

Function:
A component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

Subcellular Location:
Endoplasmic reticulum and Microsome membrane;: Single-pass type II membrane protein 

Database links:

Entrez Gene: 767917 Cow

Entrez Gene: 404005 Dog

Entrez Gene: 60559 Human

Entrez Gene: 76219 Mouse

Entrez Gene: 76976 Mouse

Entrez Gene: 100360464 Rat

Entrez Gene: 317409 Rat

SwissProt: Q3SZU5 Cow

SwissProt: P61008 Dog

SwissProt: P61009 Human

SwissProt: Q9D365 Mouse

SwissProt: Q568Z4 Rat

Unigene: 6322 Cow

Unigene: 3875 Dog

Unigene: 42194 Human

Unigene: 328305 Mouse

Unigene: 482965 Mouse

Unigene: 162344 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

信号肽复合物亚基3抗体

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