转移生长因子β受体2抗体

英文名称    TGF beta Receptor II    

中文名称    转移生长因子β受体2抗体    

别    名    TGF beta R2; TGFBR2; TGF beta Receptor II; AAT 3; AAT3; FAA 3; FAA3; HNPCC6; MFS 2; MFS2; RIIC; TAAD 2; TAAD2; TbetaR II; TGF beta receptor type 2; TGF beta receptor type II; TGF beta type II receptor; TGFB R2; TGFbeta RII; TGFBR 2; TGFBR2; TGFR 2; TGFR2; Transforming growth factor beta receptor II; Transforming growth factor beta receptor type II;    

 转移生长因子β受体2抗体   

说 明 书    0.1ml  0.2ml  1ml    

研究领域    肿瘤  细胞生物  神经生物学  信号转导  生长因子和激素  激酶和磷酸酶  细胞膜受体  细胞分化      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    62kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human TGF beta R2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

 转移生长因子β受体2抗体 产品介绍    background:
This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. 

Function:
Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

Subunit:
Homodimer. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer. The respective affinity of TGFRB1 and TGFRB2 for the ligands may modulate the kinetics of assembly of the receptor and may explain the different biological activities of TGFB1, TGFB2 and TGFB3. Interacts with DAXX. Interacts with TCTEX1D4. Interacts with ZFYVE9; ZFYVE9 recruits SMAD2 and SMAD3 to the TGF-beta receptor.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.

Post-translational modifications:
Phosphorylated on a Ser/Thr residue in the cytoplasmic domain.

DISEASE:
Defects in TGFBR2 are the cause of hereditary non-polyposis colorectal cancer type 6 (HNPCC6) [MIM:614331]. Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world, and accounts for 15% of all colon cancers. Cancers in HNPCC originate within benign neoplastic polyps termed adenomas. Clinically, HNPCC is often divided into two subgroups. Type I: hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II: patients have an increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected. HNPCC6 is a type of colorectal cancer complying with the clinical criteria of HNPCC, except that the onset of cancer was beyond 50 years of age in all cases. 

Similarity:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. 
Contains 1 protein kinase domain.

Gene ID:
7048

Database links:

Entrez Gene: 7048 Human

Entrez Gene: 21813 Mouse

Omim: 190182 Human

SwissProt: P37173 Human

SwissProt: Q62312 Mouse

Unigene: 604277 Human

Unigene: 82028 Human

Unigene: 172346 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.     

 转移生长因子β受体2抗体 

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hz-9814R C2orf44  2号染色体开放阅读框44抗体

hz-9815R C2orf42  2号染色体开放阅读框42抗体

hz-9816R C2orf43  2号染色体开放阅读框43抗体

hz-9817R C2orf55  2号染色体开放阅读框55抗体

hz-9818R C2orf57  2号染色体开放阅读框57抗体

hz-9819R C2orf69  2号染色体开放阅读框69抗体

hz-1649R phospho-APP/ABPP(Tyr757)  磷酸化APP(Tyr757)淀粉样肽前体蛋白抗体

hz-9820R C2orf89  2号染色体开放阅读框89抗体

hz-9821R C2orf29  2号染色体开放阅读框29抗体

hz-9822R C3orf24  3号染色体开放阅读框24抗体

hz-9823R AAT1/C3orf15  3号染色体开放阅读框15抗体

hz-9824R C3orf17  3号染色体开放阅读框17抗体

hz-3028R phospho-APP/ABPP(Thr668)  磷酸化APP淀粉样肽前体蛋白抗体

hz-9825R C3orf18  3号染色体开放阅读框18抗体

hz-9826R C3orf21/XXYLT1  3号染色体开放阅读框21抗体

hz-5167R phospho-APP/ABPP (Thr743)  磷酸化APP淀粉样肽前体蛋白抗体

hz-5168R phospho-APP/ABPP (Ser730)  磷酸化APP淀粉样肽前体蛋白抗体

hz-9827R C3orf23  3号染色体开放阅读框23抗体

hz-9828R C3orf33  3号染色体开放阅读框33抗体

hz-5186R phospho-APP/ABPP(Thr743)  磷酸化APP淀粉样肽前体蛋白抗体

hz-9829R C3orf37  3号染色体开放阅读框37抗体

hz-9830R C3orf39  3号染色体开放阅读框39抗体

hz-1632R APPL1  衔接因子蛋白含pH域磷酸酪氨酸结合域和亮氨酸拉链蛋白1抗体

hz-9831R C3orf49  3号染色体开放阅读框49抗体

hz-9832R C3orf54  3号染色体开放阅读框54抗体

hz-9833R C3orf59/MB21D2  3号染色体开放阅读框59抗体

hz-9836R HLC8/Lung cancer related protein 8  肺癌相关蛋白8抗体

hz-9838R C17orf59  17号染色体开放阅读框59抗体

hz-9837R C17orf104  17号染色体开放阅读框104抗体

hz-9839R C17ORF39  17号染色体开放阅读框39抗体

hz-5189R phospho-APP/ABPP(Ser198)  磷酸化APP淀粉样肽前体蛋白抗体

hz-9840R RNF213  环指蛋白213

hz-9841R HIV1 p55 + p17  艾滋病病毒p55抗体