血栓素B2(一种新发现的抑癌基因)抗体

英文名称    TBX2    

中文名称    血栓素B2(一种新发现的抑癌基因)抗体    

别    名    T-box2; Tbx21; T-box Protein 2; T-box transcription factor TBX2; T-box protein 2; FLJ10169; HGNC: 11597; T box 2; T box transcription factor TBX2; TBX2_HUMAN; TBX2.    

血栓素B2(一种新发现的抑癌基因)抗体     

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  免疫学  染色质和核信号  转录调节因子  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Cow, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    74kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human TBX2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

血栓素B2(一种新发现的抑癌基因)抗体产品介绍    background:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene.

Function:
Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence.

Subunit:
Interacts with PML (isoform-PML-2, isoform PML-3 and isoform PML-4). 

Subcellular Location:
Nucleus (Potential). 

Tissue Specificity:
Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.

Similarity:
Contains 1 T-box DNA-binding domain.

Gene ID:
30009

Database links:

Entrez Gene: 30009 Human

Entrez Gene: 57765 Mouse

Entrez Gene: 303496 Rat

Omim: 604895 Human

SwissProt: Q9UL17 Human

SwissProt: Q9JKD8 Mouse

Unigene: 272409 Human

Unigene: 94519 Mouse

Unigene: 144930 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

血栓素B2(一种新发现的抑癌基因)抗体

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