DNA拓普西异构酶ⅡA抗体

英文名称    TOP2A    

中文名称    DNA拓普西异构酶ⅡA抗体    

别    名    Topoisomerase Ⅱalpha; DNA topoisomerase II, alpha isozyme; DNA topoisomerase 2 alpha; DNA topoisomerase II 170 kD; DNA Topoisomerase2; TOP2; TOP2A; TopII alpha; Topo II alpha; Topoisomerase DNA II alpha 170kDa; Topoisomerase II alpha 170 kDa; TP2A; TPⅡA; TOP2A_HUMAN.    

DNA拓普西异构酶ⅡA抗体        

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  染色质和核信号  信号转导  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    174kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human TOP2 alpha    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

DNA拓普西异构酶ⅡA抗体产品介绍    background:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010].

Function:
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.

Subunit:
Homodimer. Interacts with COPS5.

Subcellular Location:
Cytoplasm. Nucleus, nucleoplasm. Note=Generally located in the nucleoplasm.

Post-translational modifications:
Phosphorylation has no effect on catalytic activity. However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation.

Similarity:
Belongs to the type II topoisomerase family.

Gene ID:
7153

Database links:

Entrez Gene: 7153 Human

Entrez Gene: 21973 Mouse

Entrez Gene: 360243 Rat

Omim: 126430 Human

SwissProt: P11388 Human

SwissProt: Q01320 Mouse

SwissProt: P41516 Rat

Unigene: 156346 Human

Unigene: 4237 Mouse

Unigene: 90996 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

DNA拓普西异构酶ⅡA抗体

hz-6123R PRB2/p130  视网膜母细胞瘤相关蛋白p130抗体

hz-6124R p95 NBS1/Cell cycle regulatory protein p95  细胞周期调节蛋白P95抗体

hz-6125R phospho-p95 NBS1(Ser343)  磷酸化滑膜细胞凋亡抑制物1抗体

hz-6126R FAM123B/AMER1  肾母细胞瘤X蛋白抗体

hz-6127R KARS2/Lysyl tRNA synthetase  赖氨酸tRNA的连接酶抗体

hz-6128R WSTF  转录因子WSTF抗体

hz-6129R Wnt8A  信号通路WNT8A抗体

hz-6133R WNT2  信号通路Wnt2抗体

hz-6137R CtIP/RBBP8  视网膜母细胞瘤结合蛋白8抗体

hz-6138R EID1  乙酰基转移酶EID1抗体

hz-6139R KDM5B/PLU1/Jarid1B  组蛋白去甲基化酶JARID1B抗体

hz-6140R KMT8/Riz1/Riz2  转录因子GATA3结合蛋白G3B抗体

hz-6141R GLIPR1  脑胶质瘤发病机制相关蛋白1抗体

hz-6142R RING1  环指蛋白1抗体

hz-6143R PIG3/TP53I3  p53诱导蛋白3抗体

hz-6144R PRMT4  组蛋白精氨酸甲基转移酶CARM1抗体

hz-6145R TP53I13  肿瘤蛋白p53诱导蛋白13(肿瘤抑制基因)

hz-6146R p53 DINP1  p53诱导核蛋白1抗体

hz-6147R p73 alpha  p53相关蛋白P73α抗体

hz-6148R Frizzled 1/Wnt receptor  Wnt信号受体蛋白抗体

hz-6149R GNAT3  G蛋白转录因子α3抗体

hz-6150R GPR124  G蛋白偶联受体124抗体（肿瘤血管内皮标记物）

hz-6151R GPR172B  G蛋白偶联受体172B抗体

hz-6152R GNAQ/Gα q  G蛋白α亚单位蛋白Q抗体

hz-6155R RAP1GDS1  G蛋白GTP-GDP解离刺激因子1抗体

hz-6156R RASGEF1A  鸟嘌呤核苷酸交换因子rasgef1a抗体

hz-6157R RAB4  癌基因RAS相关蛋白Rab4A抗体

hz-6158R NSP1/SH2D3A  SH2结构域蛋白3A抗体

hz-6159R STARD8  GTP酶激活因子STARD8抗体

hz-6161R WASF3  Verprolin同源结构域包含蛋白3抗体

hz-6162R ARL3  ADP核糖基化样因子ARL3抗体

hz-6163R DIRAS1  RAS相关抑细胞生长蛋白1抗体

hz-6164R GRAP2  生长因子受体结合蛋白2相关接头蛋白2抗体

hz-6166R DPOLA/DNA polymerase alpha  DNA聚合酶α抗体

hz-6167R NET1  神经上皮细胞转化基因1抗体

hz-6168R RAB8B  ras癌基因家族RAB8B抗体

hz-6169R RALB  Ras样蛋白B抗体