髓系细胞触发受体样转录因子2抗体

英文名称    TREML2    

中文名称    髓系细胞触发受体样转录因子2抗体    

别    名    C6orf76; Chromosome 6 open reading frame 76; FLJ13693; MGC149715; MGC149716; TLT 2; TLT2; TREM like transcript 2; Trem like transcript 2 protein; Triggering receptor expressed on myeloid cells like 2; Triggering receptor expressed on myeloid cells like protein 2; TRML2_HUMAN.    

髓系细胞触发受体样转录因子2抗体       

说 明 书    0.2ml      

研究领域    细胞生物  免疫学  t-淋巴细胞  b-淋巴细胞      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    33kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human TREML2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 髓系细胞触发受体样转录因子2抗体 产品介绍    background:
TREML2 is expressed throughout B cell development in addition to being expressed on macrophages and neutrophils and is the only TREM molecule to be found on lymphocytes. TREML2 is expressed on B lineage cells early in development, and the highest level of expression is detected on those mature peripheral B cell subpopulations that are involved in the initial humoral immune response against bacterial pathogens. TREML2 is unique in that it lacks either the conserved transmembrane lysine residue or ITAM/ITIMs within its own cytoplasmic domain. Thus, TREML2 does not exhibit any of the features associated with classical tyrosine-based signaling.
Monocytes in the bone marrow or peripheral blood do not express detectable levels of TREML2, but its expression is up-regulated in conjunction with differentiation into macrophages. TREML2 is present on neutrophils in the bone marrow as well as the periphery, and inflammatory stimuli result in a dramatic increase in the expression of TREML2 on these cells in vivo.
TREML2 is a single-pass type I membrane protein, and it contains 1 Ig-like V-type (immunoglobulin-like) domain. It is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 and TREM2, but it has distinct structural and functional properties. 


Function:
Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counterreceptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.

Subunit:
Interacts with CD276 and this interaction enhances T-cell activation.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.

Tissue Specificity:
Detected in cultured B cells, T cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation.

Similarity:
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Gene ID:
79865

Database links:

Entrez Gene: 79865 Human

Omim: 609715 Human

SwissProt: Q5T2D2 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

髓系细胞触发受体样转录因子2抗体 

hz-2540P GLUT12  葡萄糖转运蛋白12

hz-2558P EGFRvIII  表皮生长因子受体III型突变体抗原

hz-2570P CD26  CD26抗原

hz-1231P ABCG1 peptide  三磷酸腺苷结合盒亚家族G1抗原

hz-2804P Cardiac Troponin T  心肌特异性肌钙蛋白T

hz-0164P BACE( ASP2 )   β分泌酶（抗原）

hz-0583P ABL1(v-abl Abelson murine leukhzia viral oncogene homolog 1)  ABL1抗原

hz-2940P FUCA1/Alpha L fucosidase I peptide  α-L岩藻糖苷酶抗原

hz-0295P-AF647 Rabbit IgG/Alexa Fluor 647  Alexa Fluor 647标记兔IgG(细胞流式同型对照)

hz-0275P Bassoon(BSN)  

hz-0127P Bax peptide  Bax（多肽抗原）

hz-0409P-FIThz Leptin peptide/FITC  荧光素FITC标记瘦素抗原

hz-0032P Bcl-2(抗原)  Bcl-2（多肽抗原）

hz-0248P BDNF (Brain-derived Neurotrophin factor)  脑源神经营养因子(脑衍化神经营养因子)（多肽片断抗原）

hz-2249P ACA11 peptide  拟南芥ACA11蛋白多肽抗原

hz-2247P AHA3 peptide  植物蛋白AHA3抗原（拟南芥）

hz-0217P bFGF  碱性成纤维细胞生长因子（多肽抗原）

hz-1004P ACE2(Angiotensin converting enzyme 2)  血管紧张素转换酶2抗原

hz-0044P BNP  脑钠素（多肽抗原）

hzb-0044P BNP/Biotin  生物素化脑钠素多肽

hz-0489P BrdU (Bromodeoxyuridine)  溴脱氧尿苷

hz-0324P C5  过敏毒素C5（补体C5）抗原

hz-0091P CA125  卵巢癌抗原

hz-2190P CK19  细胞角蛋白19抗原

hz-0043P CAD(Caspase-Activated Deoxyribonuclease)  Caspase 激活的脱氧核糖核酸酶（抗原）

hz-3550P MYOG  肌红蛋白抗原

hz-0095P Calponin 1  钙调节蛋白-1（抗原）

hz-3679P COMP  软骨寡聚基质蛋白抗原

hz-0169P Caspase-1 (ICE; CASP-1；P45)  天冬氨酸-胱氨酸特异性蛋白酶家族（抗原）

hz-0081P Caspase-3 (CPP32)  半胱胺酸蛋白酶蛋白-3（抗原）

hz-0084P Caspase-6 (NT)  半胱胺酸蛋白酶蛋白-6（抗原）

hz-0151P Caspase-6 (CT)  半胱胺酸蛋白酶蛋白-6（抗原）

hz-4002P phospho-AMPK alpha 1(Thr172) peptaide  磷酸化腺苷单磷酸活化蛋白激酶α1抗原

hz-0049P Caspase-9  白介素1-β转化酶样凋亡蛋白酶6（抗原）

hz-0050P Caspase-9   白介素1-β转化酶样凋亡蛋白酶6（抗原）