英文名称 TCTN3
中文名称 结构蛋白家族3抗体
别 名 C10orf61; Chromosome 10 open reading frame 61; DKFZP564D116; TCTN3; TECT3_HUMAN; Tectonic 3; Tectonic 3 precursor; Tectonic family member 3; Tectonic-3; TECT3; UNQ1881/PRO4324; PSEC0041.
结构蛋白家族3抗体
说 明 书 0.2ml
研究领域 细胞生物 细胞凋亡 生长因子和激素
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 64kDa
细胞定位 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TCTN3/TECT3
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
结构蛋白家族3抗体产品介绍 background:
This gene encodes a member of the tectonic gene family which functions in Hedgehog signal transduction and development of the neural tube. Mutations in this gene have been associated with Orofaciodigital Syndrome IV and Joubert Syndrom 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012].
Function:
Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). May be involved in apoptosis regulation. Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway
Subunit:
Part of the tectonic-like complex (also named B9 complex) (By similarity).
Subcellular Location:
Membrane; Single-pass type I membrane protein (Potential).
DISEASE:
Defects in TCTN3 are the cause of orofaciodigital syndrome 4 (OFD4) [MIM:258860]. A form of orofaciodigital syndrome, a group of heterogeneous disorders characterized by malformations of the oral cavity, face and digits, and associated phenotypic abnormalities that lead to the delineation of various subtypes. OFD4 patients have tongue nodules, multiple frenulae, broad flat nose, hypertelorism, and short rib polydactyly with tibial dysplasia (Majewski syndrome). The presence of severe tibial aplasia differentiates OFD4 from OFD1. Additional features of cystic dysplastic kidneys and brain malformation, including occipital encephalocele, are observed in severely affected patients.
Defects in TCTN3 are the cause of Joubert syndrome 18 (JBTS18) [MIM:614815]. A form of Joubert syndrome, a disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease. JBTS18 patients have vermis agenesis and the molar tooth sign as well as severe kyphoscoliosis. Other features include intrauterine growth retardation, oral anomalies, micrognathism, polydactyly and camptodactyly, joint laxity, horseshoe kidney, and ventricular septal defect. Note=TCTN3-mutated fibroblasts from JBTS18 patients fail to respond to Shh agonists suggesting that at least some of the defects in affected individuals may be secondary to reduced Shh signaling (PubMed:22883145).
Similarity:
Belongs to the tectonic family.
Database links:
Entrez Gene: 26123 Human
Entrez Gene: 67590 Mouse
Entrez Gene: 309486 Rat
SwissProt: Q6NUS6 Human
SwissProt: Q8R2Q6 Mouse
Unigene: 438991 Human
Unigene: 374056 Mouse
Unigene: 60758 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
结构蛋白家族3抗体
hz-6570R RING5 环指蛋白5抗体(E3泛素蛋白连接酶RNF5)
hz-6571R RPL15 核糖体蛋白L15抗体
hz-6572R RPL19 核糖体蛋白L19抗体
hz-6573R RPL5 核糖体蛋白L5抗体
hz-6574R RRBP1 核糖体结合蛋白1抗体
hz-6575R S100A7/Psoriasin S100钙结合蛋白A7抗体
hz-6576R RBBP6 视网膜母细胞瘤结合蛋白6抗体
hz-6577R S100PBP/S100P binding protein S100P结合蛋白抗体
hz-6578R SAMD14 SAMD14抗体
hz-6580R CDMP1/GDF5 软骨衍生形态发生蛋白1抗体
hz-6581R RNA polymerase II CTD repeat YSPTSPS (phospho S2) 磷酸化RNA聚合酶II CTD抗体
hz-6582R RNA polymerase II CTD repeat YSPTSPS (phospho S5) 磷酸化RNA聚合酶II CTD抗体
hz-6583R RNASE4/Angiogenin 血管生成素核糖核酸酶4抗体(肌萎缩性侧索硬化症蛋白)
hz-6584R DUT 脱氧尿苷三磷酸酶DUT抗体
hz-6585R Desmoglein 3/DSG3 桥粒芯蛋白3抗体
hz-6586R FCAR/CD89 免疫球蛋白A Fc段受体1抗体
hz-6587R APEX2 嘌呤嘧啶核酸内切酶2抗体
hz-6588R ADAMTS10 整合素样金属蛋白酶与凝血酶10型抗体
hz-6589R BCAT2/BCAM 支链氨基酸转氨酶2抗体
hz-6590R Bcl2A1 BCL2相关蛋白A1抗体
hz-6591R Bcl3 B细胞淋巴瘤蛋白3抗体
hz-6592R HSD17B6 17-β-羟脱氢酶6抗体
hz-6593R TFF1/BCEI 乳腺癌雌激素诱导蛋白抗体
hz-6594R Galectin 1 半乳糖凝集素1抗体
hz-6595R CENPB 着丝粒蛋白B抗体
hz-6596R STMN3 原癌基因18家族STMN3蛋白抗体
hz-6597R NPHS2/Podocin 肾小球裂孔膜蛋白PDCN抗体
hz-6598R Cofilin 肌动蛋白结合蛋白CFL抗体
hz-6599R EphA5/Eph receptor A5 酪氨酸蛋白激酶A5受体抗体
hz-6600R HHEX/HMPH 同源盒蛋白PRH抗体
hz-5164R ETS1 associated protein II/EAPII ETS1相关蛋白2抗体
hz-6601R TLR7 Toll样受体7抗体
hz-6603R HSD17B1/HSD17 羟类固醇脱氢酶17β抗体
hz-6604R BCNG1/HCN1 脑环核苷酸门控通道蛋白1抗体
hz-6605R BCAS3 乳腺癌相关蛋白3抗体
hz-6606R MRGX1/MRGPRC/SNSR G蛋白偶联受体MRGX1抗体
hz-6607R TSPY1 睾丸特异定蛋白质编码Y1抗体
更多
企业名称
上海沪震实业有限公司
企业信息已认证
企业类型
信用代码
310112001371133
成立日期
2012-05-08
注册资本
100
经营范围
实验室分析仪器、仪器仪表、电子产品、化工产品及原料(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品)、一类医疗器械的销售,实业投资,投资咨询(除经纪),景观设计,从事生物科技领域内的技术开发、技术转让、技术咨询、技术服务,建筑装修装饰建设工程专业施工(凭许可资质经营),汽车租赁(除融资租赁)。【依法须经批准的项目,经相关部门批准后方可开展经营活动】
上海沪震实业有限公司
公司地址
上海市杨浦区密云路1018号复旦科技园808室
客服电话