英文名称 TIN-Ag
中文名称 肾小管间质肾炎抗原抗体
别 名 TINAG; TIN AG; TIN-Ag; TIN1; TIN2; TINAG; TINAG_HUMAN; Tubulointerstitial nephritis antigen.
肾小管间质肾炎抗原抗体
说 明 书 0.2ml
研究领域 细胞生物 免疫学 信号转导
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Cow, Horse, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
细胞定位 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TIN-Ag
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
肾小管间质肾炎抗原抗体产品介绍 background:
Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein.
Function:
Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein.
Subcellular Location:
Secreted; extracellular space; extracellular matrix; basement membrane.
Tissue Specificity:
Expressed in the kidney cortex, small intestine and cornea.
Post-translational modifications:
It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus 2 alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
DISEASE:
Initially observed in the Bowman capsule during early glomerular capillary loop formation in the kidney. In more developmentally mature glomeruli, following transition from early to mid-capillary loop stage, expression is higher in the proximal tubular basement membrane than in the distal basement membrane and Bowman capsule.
Similarity:
Belongs to the peptidase C1 family.
Contains 1 SMB (somatomedin-B) domain.
Database links:
Entrez Gene: 27283 Human
Omim: 606749 Human
SwissProt: Q9UJW2 Human
Unigene: 127011 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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