张力蛋白4抗体

英文名称    TNS4    

中文名称    张力蛋白4抗体    

别    名    C terminal tensin like; C terminal tensin like protein; C-terminal tensin-like protein; CTEN; FLJ14950; PP14434; TENS4_HUMAN; Tensin 4; Tensin-4; Tns4.    

张力蛋白4抗体        

说 明 书    0.2ml      

研究领域    肿瘤  细胞生物  信号转导  细胞粘附分子  细胞骨架      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    75kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human TNS4    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

张力蛋白4抗体  产品介绍    background:
The Tensin (Tns) family of proteins is involved in the maintenance of cellular structure by anchoring Actin filaments at the focal adhesion via F-Actin binding and capping activities. Tns proteins contain a Src homology 2 (SH2) domain and have the ability to be phosphorylated, suggesting an additional role in signal transduction cascades. These diverse characteristics indicate that Tns proteins may be important links between the cytoskeleton and signal transduction pathways. Tns4 is a 715 amino acid protein that localizes to focal adhesions and contains one SH2 domain and one phosphatase tensin-type domain. Expressed in placenta and prostate, Tns4 binds to Actin filaments and is thought to be involved in cartilage development, cell migration and apoptosis, and may also play a role in linking signal transduction pathways to the cytoskeleton. Tns4 is subject to post-translational phosphorylation and is down-regulated in prostate cancer cells, suggesting a role in tumor suppression

Function:
May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3.

Subcellular Location:
Cell junction > focal adhesion. Cytoplasm > cytoskeleton.

Tissue Specificity:
Prostate and placenta. Down regulated in prostate cancer.

Post-translational modifications:
Proteolytically cleaved by caspase-3 during apoptosis.

Similarity:
Contains 1 phosphatase tensin-type domain.
Contains 1 SH2 domain.

Gene ID:
84951

Database links:

Entrez Gene: 84951 Human

Entrez Gene: 217169 Mouse

Omim: 608385 Human

SwissProt: Q8IZW8 Human

SwissProt: Q8BZ33 Mouse

Unigene: 438292 Human

Unigene: 262067 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

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