英文名称 Unc18-3
中文名称 突触囊泡融合蛋白Unc18-3抗体
别 名 Munc 18 3; Munc18 3; Munc 18-3; Protein unc-18 homolog 3; STXB3_HUMAN.
突触囊泡融合蛋白Unc18-3抗体
说 明 书 0.2ml
研究领域 肿瘤 细胞生物 免疫学 神经生物学 信号转导
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
产品应用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 68kDa
细胞定位 细胞浆 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Unc18-3
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
突触囊泡融合蛋白Unc18-3抗体产品介绍 background:
May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
Function:
Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity).
Subunit:
Interacts with DOC2B; the interaction is direct, occurs at the cell membrane, excludes interaction with STX4 and regulates glucose-stimulated insulin secretion (By similarity). Interacts with STX4.
Subcellular Location:
Cytoplasm, cytosol. Cell membrane.
Tissue Specificity:
Megakaryocytes and platelets.
Similarity:
Belongs to the STXBP/unc-18/SEC1 family.
Database links:
UniProtKB/Swiss-Prot: O00186.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
突触囊泡融合蛋白Unc18-3抗体
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