尿路上皮特异蛋白3抗体

英文名称    UPK3A    

中文名称    尿路上皮特异蛋白3抗体    

别    名    Uroplakin III; MGC119178; OTTHUMP00000028951; UP III; UP3A; UPIII; UPIIIA; UPK 3; UPK 3A; UPK3; UPK3A; UPK3A_HUMAN; Uroplakin 3A; Uroplakin III; Uroplakin-3a; Uroplakin3A; UroplakinIII.    

尿路上皮特异蛋白3抗体       

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞分化      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig, Cow, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    29kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human UPK3A    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

尿路上皮特异蛋白3抗体 产品介绍    background:
The asymmetric unit membrane (AUM) forms numerous plaques, which cover the apical surface of the urothelium. These plaques are thought to strengthen the urothelium and reduce the risk of rupturing during ladder distention. They are composed of four major integral membrane proteins called uroplakins (UP). The uroplakin family comprises UPIa, UPIb, UPII, and UPIII. Family members are conserved among several species, including human, mouse, rat, rabbit, dog, pig and sheep. UPIa and UPIb form tightly packed structures with UPII and UPIII, respectively. This pairing is required for normal urothelial plaque formation and is regulated by proteolytic processing of the uroplakin proteins. Uroplakins are expressed in normal urothelium and are used as specific markers of urothelial differentiation. They are also expressed in a majority of transitional cell carcinomas of the bladder (TCCs), which make the uroplakins a useful marker for detecting bladder cancer metastasis and for staging and monitoring chemotherapeutic response.

Function:
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.

Subcellular Location:
Endoplasmic reticulum membrane. Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).

Tissue Specificity:
Expressed in ureter.

DISEASE:
Defects in UPK3A are a cause of renal adysplasia (RADYS) [MIM:191830]; also known as renal agenesis or renal aplasia. Renal agenesis refers to the absence of one (unilateral) or both (bilateral) kidneys at birth. Bilateral renal agenesis belongs to a group of perinatally lethal renal diseases, including severe bilateral renal dysplasia, unilateral renal agenesis with contralateral dysplasia and severe obstructive uropathy.

Similarity:
Belongs to the uroplakin-3 family.

Gene ID:
7380

Database links:

Entrez Gene: 7380 Human

Omim: 611559 Human

SwissProt: O75631 Human

SwissProt: Q32N05 Human

Unigene: 632787 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

尿路上皮特异蛋白3抗体 

hz-0329P TRA16 (Testicular orphan nuclear receptor-4 (TR4)-associated protein)  睾丸激素受体相关蛋白/孤儿素受体相关蛋白(抗原)

hz-1202P TRADD(TNF receptor 1 associated via death domain)  有死亡区的肿瘤坏死因子受体1相关蛋白抗原

hz-1212P TRAF1  肿瘤坏死因子受体相关因子1抗原

hz-1213P TRAF2/TNF-R2 (TNF receptor-associated factor 2)  肿瘤坏死因子受体相关因子2抗原

hz-1185P TRAF3/CD40bp (CD40 binding protein)  肿瘤坏死因子受体相关蛋白3抗原

hz-1184P TRAF6 (TNF receptor-associated factor 6)  肿瘤坏死因子受体相关因子6抗原

hz-1214P TRAIL/Apo2L (tumor necrosis factor-related apoptosis-inducing ligand)  肿瘤坏死因子相关凋亡诱导配体/凋亡素2配体抗原

hz-1151P TRBF1 (Telomeric repeat binding factor 1)  端粒体复制结合因子1抗原

hz-0964P TRIM32(tripartite motif protein 32)  TRIM32抗原

hz-1243P Trop-2/Tpm2 peptide  原肌球蛋白抗原

hz-1220P TSARG4(Testis and spermatogenesis related gene 4)  生精细胞凋亡相关基因4抗原

hz-0546P TSGF(Tumor Specific Growth Fanctor)  恶性肿瘤特异性生长因子抗原

hz-0716P CIDEB peptide  CIDEB抗原

hz-1365P Tsg101(Tumor susceptibility gene 101 protein)  Tsg101抗原

hz-2087P TSHR (Thyroid stimulating hormone receptor)  促甲状腺素受体抗原

hz-1534P MAP1LC3A(microtubule-associated protein 1 light chain 3)  自噬微管相关蛋白轻链3抗原

hz-1147P TSLC1 (tumor suppressor in lung cancer-1)  肺癌肿瘤阻抑基因1抗原

hz-0826P TTF-1 (Thyroid Transcription Factor-1)  甲状腺核转录因子-1抗原

hz-1322P Tubulin- Gamma  微管蛋白-γ抗原

hz-2441P TWIST protein peptide  TWIST蛋白抗原

hz-1088P T Beta10 peptide  胸腺素β10抗原

hz-1929P UCN(Urocortin)mouse ret  新型血管活性因子UCN抗原(小鼠、大鼠)

hz-1403P USF-1(upstream stimulatory factor 1)  上游刺激因子1抗原

hz-1549P Ubiquitin  泛素蛋白

hz-1505P VASH1(Vasohibin 1)  兔抗血管抑制蛋白1抗原

hz-0396P VCAM-1/CD106(Vascular cell adhesion molecule 1 isoform b precusor; CD106 antigen)  血管内皮细胞粘附分子抗原

hz-0920P VCAM-1/CD106 (Vascuolar cell adhesion molecule 1)  血管内皮细胞粘附分子抗原

hz-1461P VDAC peptide  电压依赖性阴离子通道抗原

hz-1313P VEGF  血管内皮生长因子(多肽抗原)

hz-1957P VEGF-A(Vascuoar endothelial growth factor A)  血管内皮生长因子A抗原

hz-1586P VEGF-C(Vascuoar endothelial growth factor-C)  血管内皮生长因子C型抗原

hz-0565P VEGFR2  血管内皮生长因子受体2

hz-2089P sVEGFR2  可溶性血管内皮生长因子受体2

hz-1083P VEGFR-3/FLt-4  血管内皮细胞生长因子受体-3（多肽）