神经突起生长诱导因子受体Unc5a抗体

英文名称    Unc5a    

中文名称    神经突起生长诱导因子受体Unc5a抗体    

别    名    UNC5H1; Netrin receptor UNC 5A; Netrin receptor UNC5A; Netrin receptor Unc5h1; Protein unc-5 homolog 1; Protein unc-5 homolog A; Unc 5 homolog 1; Unc 5 homolog A; Unc 5a; Unc5 a; Unc5 homolog 1; Unc5 homolog A; Unc5a; UNC5A_HUMAN; Unc5h1; FLJ16449; KIAA1976.    

神经突起生长诱导因子受体Unc5a抗体     

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  神经生物学  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    90kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Unc5a    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

神经突起生长诱导因子受体Unc5a抗体  产品介绍    background:
The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is downregulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung and kidney cancers. UNC5H1, also known as UNC5HA (unc-5 homolog A), is a member of the UNC5H family of proteins and is localized to the cell membrane. Three isoforms of UNC5H1 exist due to alternative splicing events.

Function:
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.

Subunit:
Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly mediating some interaction with PKC

Subcellular Location:
Cell membrane. The interaction with PRKCABP regulates its surface expression and leads to its removal from surface of neurons and growth cones.

Post-translational modifications:
Phosphorylated on cytoplasmic tyrosine residues. Phosphorylated by PKC in vitro.
Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.

Similarity:
Belongs to the unc-5 family.
Contains 1 death domain.
Contains 1 Ig-like (immunoglobulin-like) domain.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 TSP type-1 domain.
Contains 1 ZU5 domain.

Database links:

Entrez Gene: 90249 Human

Entrez Gene: 107448 Mouse

Entrez Gene: 60629 Rat

Omim: 607869 Human

SwissProt: Q6ZN44 Human

SwissProt: Q8K1S4 Mouse

SwissProt: O08721 Rat

Unigene: 33191 Human

Unigene: 23573 Mouse

Unigene: 44433 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

神经突起生长诱导因子受体Unc5a抗体  

hz-1790P CRMP2/Dpysl2(collapsin response mediator protein-2)  二氢嘧啶酶样2CRMP2抗原

hz-1860P CRLR/CALCRL(calcitonin receptor like precursor)  降钙素受体样蛋白抗原

hz-1703P cRaf/Raf1(c-raf 1)  cRaf/Raf1抗原

hz-1433P MEK1/MAPKK1(mitogen activated protein kinase kinase 1)  MEK1/MAPKK1抗体(N-端)

hz-0382P CRF (Corticotropin-Releasing Factor)  促肾上腺皮质激素释放因子

hz-0793P CSIG(cellular senescence inhibited gene)  细胞衰老抑制基因抗原

hz-1566P Cripto-1(N-Terminus)  畸胎瘤衍化生长因子抗原(表皮生长因子相关肽)N端

hz-2141P Cripto-1(C-Terminus)  畸胎瘤衍化生长因子抗原(表皮生长因子相关肽)C端

hz-0848P Anti-CSP (circumsporozoite protein/Plasmodium yoelii)  环子孢子蛋白(约氏疟原虫)抗原

hz-2174P Calcitonin  降钙素抗原

hz-1410P CTBP1(C-terminal binding protein 1)  C端结合蛋白1抗原

hz-1179P CTLA-4/CD152  淋巴细胞相关抗原4/细胞毒性T细胞抗原-4

hz-0799P CTn1 (cardiac troponin 1)  心肌肌钙蛋白

hz-1376P Cx32(Connexin-32)  间隙连接蛋白32抗原

hz-1266P CX36 (Connexin-36)  间隙连接蛋白36抗原

hz-1050P Cx40 (Connexin-40)  间隙连接蛋白40(多肽)

hz-0811P cx3cl1(chhzokine (C-X3-C motif) ligand 1)  趋化因子(C-X3-C 基元)配体1抗原

hz-1728P CX3CR1(CX3C-chhzokine receptor 1)  CX3C趋化因子受体1抗原

hz-0571P Cyclin A  周期素A抗原

hz-0572P Cyclin B1  周期素B1抗原

hz-1148P Cyclin D2  周期素D2抗原

hz-0660P Cyclin D3(C-term)  周期素D3抗原

hz-1742P CYP3A4(Cytochrome p450 3A4)  细胞色素P450 3A4抗原

hz-1290P Cyr61/IGFBP10/CCN1(cysteine rich 61)  富半胱氨酸肝素结合蛋白61抗原

hz-0896P HCMV UL23/HHV5 UL23(Human Cytomegalovirus UL23 Gene)  人巨细胞病毒UL23抗原

hz-1007P DAD1 (dopamine D1 receptor)  多巴胺受体-D1抗原

hz-1743P DRD3 receptor(dopamine D3 receptor)  多巴胺受体-D3抗原

hz-1746P DRD4 receptor peptide  多巴胺受体-D4抗原

hz-1747P DRD5 receptor(dopamine D5 receptor)  多巴胺受体-D5抗原

hz-0596P DBH (Dopamine- Beta-Hydroxylase)  多巴胺β羟化酶（抗原）

hz-0592P DCC (Deleted in colorectal cancer gene)  结直肠癌缺失基因抗原

hz-1269P DCX(Doublecortin)  双皮质素抗原

hz-2599P DDB2(DNA damage-binding protein 2)  损伤DNA结合蛋白2抗原

hz-1163P Defensin Beta1  防御素β1抗原

hz-2165P Defensin Beta1(human)  防御素β1抗原(人)

hz-1295P Defensin Beta2/beta-defensin 2/BD-2(mouse)  防御素β2抗原（小鼠）

hz-1296P Defensin Beta2/beta-defensin 2/BD-2(rat)  防御素β2抗原（大鼠）

hz-1687P DAPK1(Death associated protein kinase 1)  凋亡相关蛋白激酶1抗原