磷酸化泛素交联酶抗体

英文名称    Phosphor-UBE2s(Thr152)    

中文名称    磷酸化泛素交联酶抗体    

别    名    UBE2s(Phosphor T152); Phosphor-UBE2s(T152); E2 EPF; E2EPF; EPF5; UBE2S; Ubiquitin carrier protein S; Ubiquitin conjugating enzyme E2 24 kD; Ubiquitin conjugating enzyme E2S; Ubiquitin protein ligase S; AA409170; MGC101982; UBE2S_HUMAN.    

磷酸化泛素交联酶抗体      

说 明 书    0.1ml      

产品类型    磷酸化抗体     

研究领域    免疫学  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    24kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthesised phosphopeptide derived from human UBE2s around the phosphorylation site of Thr152    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷酸化泛素交联酶抗体 产品介绍    background:
This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]

Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination.

Subunit:
Component of the APC/C complex. Interacts with CDC20, FZR1/CDH1 and VHL.

Post-translational modifications:
Autoubiquitinated by the APC/C complex during G1, leading to its degradation by the proteasome.

Similarity:
Belongs to the ubiquitin-conjugating enzyme family.

Gene ID:
27338

Database links:

Entrez Gene: 617703 Cow

Entrez Gene: 27338 Human

Entrez Gene: 77891 Mouse

Entrez Gene: 292588 Rat

GenBank: NP_055316.2 Human

Omim: 610309 Human

SwissProt: Q1RML1 Cow

SwissProt: Q16763 Human

SwissProt: Q921J4 Mouse

SwissProt: B5DFI8 Rat

Unigene: 396393 Human

Unigene: 389787 Mouse

Unigene: 120398 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

磷酸化泛素交联酶抗体 

hz-0377R-AF555 Rabbit Anti-mouse IgG-Fc/Alexa Fluor 555  Alexa Fluor 555标记的兔抗小鼠IgG-Fc

hz-0377R-AF647 Rabbit Anti-mouse IgG-Fc/Alexa Fluor 647  Alexa Fluor 647标记的兔抗小鼠IgG-Fc

hz-0377R-PE-hzy5.5 Rabbit Anti-mouse IgG-Fc/PE-Cy5.5  PE-Cy5.5标记的兔抗小鼠IgG-Fc

hz-0377R-PE-hzy7 Rabbit Anti-mouse IgG-Fc/PE-Cy7  PE-Cy7标记的兔抗小鼠IgG-Fc

hz-0377R-AP Rabbit Anti-mouse IgG-Fc/AP  碱性磷酸酶（AP）标记的兔抗小鼠IgG-Fc

hz-0377R-Gold Rabbit Anti-mouse IgG-Fc/Gold  胶体金标记的兔抗小鼠IgG-Fc

hz-0377R-hzy3 Rabbit Anti-mouse IgG-Fc/Cy3  Cy3标记的兔抗小鼠IgG-Fc

hz-0377R-hzy5 Rabbit Anti-mouse IgG-Fc/Cy5  Cy5标记的兔抗小鼠IgG-Fc

hz-0377R-hzy5.5 Rabbit Anti-mouse IgG-Fc/Cy5.5  Cy5.5标记的兔抗小鼠IgG-Fc

hz-0377R-hzy7 Rabbit Anti-mouse IgG-Fc/Cy7  Cy7标记的兔抗小鼠IgG-Fc

hz-0377R-PE Rabbit Anti-mouse IgG-Fc/PE  PE标记的兔抗小鼠IgG-Fc

hz-0377R-FIThz Rabbit Anti-mouse IgG-Fc/FITC  FITC标记的兔抗小鼠IgG-Fc

hz-0377R-RBIThz Rabbit Anti-mouse IgG-Fc/RBITC  罗丹明标记的兔抗小鼠IgG-Fc

hz-0377R-Bio Rabbit Anti-mouse IgG-Fc/Bio  生物素标记的兔抗小鼠IgG-Fc

hz-0335R-RBIThz Rabbit Anti-Monkey IgG/RBITC  罗丹明标记的兔抗猴IgG

hz-0335R-FIThz Rabbit Anti-Monkey IgG/FITC  FITC标记的兔抗猴IgG

hz-0335R-HRP Rabbit Anti-Monkey IgG/HRP  辣根过氧化物酶标记的兔抗猴IgG

hz-0335R-Gold Rabbit Anti-Monkey IgG/Gold  胶体金标记的兔抗猴IgG

hz-0335R-AP Rabbit Anti-Monkey IgG/AP  碱性磷酸酶（AP）标记的兔抗猴IgG

hz-0335R-Bio Rabbit Anti-Monkey IgG/Bio  生物素标记的兔抗猴IgG

hz-0335R-hzy3 Rabbit Anti-Monkey IgG/Cy3  Cy3标记的兔抗猴IgG

hz-0335R-hzy5 Rabbit Anti-Monkey IgG/Cy5  Cy5标记的兔抗猴IgG

hz-0335R-hzy5.5 Rabbit Anti-Monkey IgG/Cy5.5  Cy5.5标记的兔抗猴IgG

hz-0335R-hzy7 Rabbit Anti-Monkey IgG/Cy7  Cy7标记的兔抗猴IgG

hz-0335R-PE Rabbit Anti-Monkey IgG/PE  PE标记的兔抗猴IgG

hz-0335R-PE-hzy3 Rabbit Anti-Monkey IgG/PE-Cy3  PE-Cy3标记的兔抗猴IgG

hz-0335R-PE-hzY5 Rabbit Anti-Monkey IgG/PE-CY5  PE-CY5标记的兔抗猴IgG

hz-0335R-APhz Rabbit Anti-Monkey IgG/APC  APC标记的兔抗猴IgG

hz-0335R-AF350 Rabbit Anti-Monkey IgG/Alexa Fluor 350  Alexa Fluor 350标记的兔抗猴IgG

hz-0335R-AF488 Rabbit Anti-Monkey IgG/Alexa Fluor 488  Alexa Fluor 488标记的兔抗猴IgG

hz-0335R-AF555 Rabbit Anti-Monkey IgG/Alexa Fluor 555  Alexa Fluor 555标记的兔抗猴IgG

hz-0335R-AF647 Rabbit Anti-Monkey IgG/Alexa Fluor 647  Alexa Fluor 647标记的兔抗猴IgG

hz-0335R-PE-hzy5.5 Rabbit Anti-Monkey IgG/PE-Cy5.5  PE-Cy5.5标记的兔抗猴IgG