尿路上皮特异蛋白1a抗体

英文名称    Uroplakin Ia    

中文名称    尿路上皮特异蛋白1a抗体    

别    名    UPK1A_HUMAN; Uroplakin-1a; UP1a; Tetraspanin-21; Tspan-21; Uroplakin Ia; UPIa; UPKa.    

尿路上皮特异蛋白1a抗体    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  信号转导  跨膜蛋白      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig, Cow, Horse, Sheep,     

产品应用    WB=1:100-500 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    29kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Uroplakin Ia    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

尿路上皮特异蛋白1a抗体    产品介绍    background:
The asymmetric unit membrane (AUM) forms numerous plaques, which cover the apical surface of the urothelium. These plaques are thought to strengthen the urothelium and reduce the risk of rupturing during ladder distention. They are composed of four major integral membrane proteins called uroplakins (UP). The uroplakin family comprises UPIa, UPIb, UPII, and UPIII. Family members are conserved among several species, including human, mouse, rat, rabbit, dog, pig and sheep. UPIa and UPIb form tightly packed structures with UPII and UPIII, respectively. This pairing is required for normal urothelial plaque formation and is regulated by proteolytic processing of the uroplakin proteins. Uroplakins are expressed in normal urothelium and are used as specific markers of urothelial differentiation. They are also expressed in a majority of transitional cell carcinomas of the bladder (TCCs), which make the uroplakins a useful marker for detecting bladder cancer metastasis and for staging and monitoring chemotherapeutic response.

Function:
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.

Subunit:
Homodimer; disulfide-linked. Interacts with uroplakin-2 (UPK2).

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
High expression restricted to ureteric urothelium (most superficial cells); low expression in prostate. Expression in normal urothelial cells is lost in culture. Some expression in tumor cell lines derived from urothelial malignancies.

Similarity:
Belongs to the tetraspanin (TM4SF) family.

Gene ID:
11045

Database links:

Entrez Gene: 11045 Human

Omim: 611557 Human

SwissProt: O00322 Human

SwissProt: Q3KNU5 Human

SwissProt: Q3KNU6 Human

Unigene: 159309 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

尿路上皮特异蛋白1a抗体    

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hz-0314R-AF350 Rabbit Anti-chicken IgM/Alexa Fluor 350  Alexa Fluor 350标记的兔抗鸡IgM

hz-0314R-AF488 Rabbit Anti-chicken IgM/Alexa Fluor 488  Alexa Fluor 488标记的兔抗鸡IgM

hz-0314R-AF555 Rabbit Anti-chicken IgM/Alexa Fluor 555  Alexa Fluor 555标记的兔抗鸡IgM

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hz-0303R-HRP Rabbit Anti-dog IgG/HRP  辣根过氧化物酶标记的兔抗狗IgG

hz-0303R-AP Rabbit Anti-dog IgG/AP  碱性磷酸酶（AP）标记的兔抗狗IgG

hz-0303R-hzy3 Rabbit Anti-dog IgG/Cy3  Cy3标记的兔抗狗IgG

hz-0303R-hzy5 Rabbit Anti-dog IgG/Cy5  Cy5标记的兔抗狗IgG

hz-0303R-hzy5.5 Rabbit Anti-dog IgG/Cy5.5  Cy5.5标记的兔抗狗IgG

hz-0303R-hzy7 Rabbit Anti-dog IgG/Cy7  Cy7标记的兔抗狗IgG

hz-0303R-PE Rabbit Anti-dog IgG/PE  PE标记的兔抗狗IgG

hz-0303R-PE-hzy3 Rabbit Anti-dog IgG/PE-Cy3  PE-Cy3标记的兔抗狗IgG

hz-0303R-PE-hzY5 Rabbit Anti-dog IgG/PE-CY5  PE-CY5标记的兔抗狗IgG

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hz-0303R-AF350 Rabbit Anti-dog IgG/Alexa Fluor 350  Alexa Fluor 350标记的兔抗狗IgG

hz-0303R-AF647 Rabbit Anti-dog IgG/Alexa Fluor 647  Alexa Fluor 647标记的兔抗狗IgG

hz-0303R-PE-hzy5.5 Rabbit Anti-dog IgG/PE-Cy5.5  PE-Cy5.5标记的兔抗狗IgG

hz-0303R-PE-hzy7 Rabbit Anti-dog IgG/PE-Cy7  PE-Cy7标记的兔抗狗IgG

hz-0303R-RBIThz Rabbit Anti-dog IgG/RBITC  罗丹明标记的兔抗狗IgG

hz-0303R-Gold Rabbit Anti-dog IgG/Gold  胶体金标记的兔抗狗IgG

hz-0303R-FIThz Rabbit Anti-dog IgG/FITC  FITC标记的兔抗狗IgG

hz-0303R-AF488 Rabbit Anti-dog IgG/Alexa Fluor 488  Alexa Fluor 488标记的兔抗狗IgG

hz-0303R-AF555 Rabbit Anti-dog IgG/Alexa Fluor 555  Alexa Fluor 555标记的兔抗狗IgG

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hz-0294R-FIThz Rabbit Anti-Goat IgG/FITC  FITC标记的兔抗羊IgG

hz-0294R-hzy3 Rabbit Anti-Goat IgG/Cy3  Cy3标记的兔抗羊IgG

hz-0294R-hzy5 Rabbit Anti-Goat IgG/Cy5  Cy5标记的兔抗羊IgG

hz-0294R-hzy5.5 Rabbit Anti-Goat IgG/Cy5.5  Cy5.5标记的兔抗羊IgG

hz-0294R-hzy7 Rabbit Anti-Goat IgG/Cy7  Cy7标记的兔抗羊IgG

hz-0294R-PE Rabbit Anti-Goat IgG/PE  PE标记的兔抗羊IgG