液泡分选蛋白4抗体

英文名称    VPS4a    

中文名称    液泡分选蛋白4抗体    

别    名    hVPS4; SKD1; SKD1 homolog; SKD2; Vacuolar protein sorting 4 homolog A; vacuolar sorting protein 4; VPS4.    

液泡分选蛋白4抗体          

说 明 书    0.2ml      

研究领域    细胞生物  细胞周期蛋白  细胞分化      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Rabbit, Zebrafish    

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    48kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human VPS4a    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

液泡分选蛋白4抗体    产品介绍    background:
Involved in intracellular protein transport probably out of a prevacuolar endosomal compartment. May be involved in the release of components of the bilayered coat from the endosomal membrane. The association with ESCRT-III complex mediates the ATP-dependent disassembly of the ESCRT-III complex. In case of infection, the HIV-1 virus takes advantage of it for budding and exocytic cargos of viral proteins.

Function:
Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Involved in cytokinesis.

Subunit:
Proposed to be monomeric or homodimeric in nucleotide-free form and to oligomerize upon binding to ATP to form two stacked hexameric or heptameric rings with a central pore through which ESCRT-III substrates are translocated in an ATP-dependent manner (By similarity). Interacts with CHMP1A, CHMP1B, CHMP2A, CHMP2B, CHMP3, CHMP4A, CHMP4B, CHMP4C and CHMP6. Interacts with VPS4B; the interaction suggests a heteromeric assembly with VPS4B. Interacts with SPAST. Interacts with IST1.

Subcellular Location:
Prevacuolar compartment membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein (Probable). Note=Membrane-associated in the prevacuolar endosomal compartment. Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.

Tissue Specificity:
Ubiquitously expressed.

Similarity:
Belongs to the AAA ATPase family.
Contains 1 MIT domain. 

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

液泡分选蛋白4抗体  

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hz-2129R Morphine  吗啡抗体

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hz-3590R Torc2/Crtc2  CREB转录共激活因子TORC2抗体

hz-3415R Phospho-Torc2/Crtc2(Ser171)  磷酸化CREB转录共激活因子TORC2抗体

hzm-2129M Morphine(2F11)  吗啡单克隆抗体

hzm-2069M Ketamine(4E2)  氯胺酮抗体

hz-4128R MAP4  微管相关蛋白4抗体

hz-4134R MAP4K1  造血祖细胞激酶1抗体

hz-5494R phospho-MAP4K1(Ser171)  磷酸化造血祖细胞激酶抗体

hzm-2070M Amphetamine(2A3F6)  苯丙胺单克隆抗体（安非他明）

hzm-2117M Cocaine(C2F1)  可卡因单克隆抗体

hz-5438R phospho-MAP4(Ser941)  磷酸化微管相关蛋白4抗体

hz-5439R phospho-MAP4(Ser1046)  磷酸化微管相关蛋白4抗体

hz-5468R phospho-MAP4(Ser1073)  磷酸化微管相关蛋白4抗体

hz-4133R MAP4K4  丝裂原活化蛋白激酶MAP4K4抗体

hz-5491R phospho-MAP4K4(Ser629)  磷酸化丝裂原活化蛋白激酶MAP4K4抗体

hz-5492R phospho-MAP4K4(Ser631)  磷酸化丝裂原活化蛋白激酶MAP4K4抗体

hz-5493R phospho-MAP4K4(Ser801)  磷酸化丝裂原活化蛋白激酶MAP4K4抗体

hz-1041R MEK1/2(MAPKK1)  丝裂原活化蛋白激酶激酶1抗体

hz-0223R MEK2/MAPKK2  丝裂原活化蛋白激酶激酶2抗体

hz-2908R MAPKAP Kinase 2  丝裂原活化蛋白激酶活化的蛋白激酶2抗体

hz-3261R Phospho-MAPKAPK2 (Thr222)  磷酸化丝裂原活化蛋白激酶活化的蛋白激酶2抗体

hz-3262R Phospho-MAPKAPK2(Thr334)  磷酸化丝裂原活化蛋白激酶活化的蛋白激酶2抗体

hz-5503R Phospho-MAPKAPK2(Ser272)  磷酸化丝裂原活化蛋白激酶活化的蛋白激酶2抗体

hz-5426R phospho-MEK2(Tyr78)  磷酸化丝裂原活化蛋白激酶激酶2抗体

hz-1976R Matrilin 1  软骨基质蛋白抗体

hz-5427R phospho-MEK2(Thr394)  磷酸化丝裂原活化蛋白激酶激酶2抗体

hz-5498R phospho-MEK2(Ser226)  磷酸化丝裂原活化蛋白激酶激酶2抗体

hz-1425R MAP3K5/ASK1/MEKK5  细胞凋亡信号调节激酶1抗体

hz-3007R phospho-ASK1 (Ser966)  磷酸化细胞凋亡信号调节激酶1抗体

hz-3029R phospho-ASK1(Ser967)  磷酸化细胞凋亡信号调节激酶1抗体

hz-3031R phospho-ASK1(Thr845)  磷酸化细胞凋亡信号调节激酶1抗体

hz-5436R phospho-ASK1(Ser83)  磷酸化细胞凋亡信号调节激酶1抗体