波形蛋白抗体

英文名称    Vimentin    

中文名称    波形蛋白抗体    

别    名    VIM; FLJ36605; OTTHUMP00000019224; VIM; VIME_HUMAN; Vimentin.    

波形蛋白抗体         

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  免疫学  信号转导  干细胞  细胞骨架  肿瘤细胞生物标志物      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    51kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Vimentin    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

波形蛋白抗体 产品介绍    background:
This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009]

Function:
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. Subunit : Homopolymer assembled from elementary dimers. Interacts with HCV core protein. Interacts with LGSN and SYNM. Interacts (via rod region) with PLEC (via CH 1 domain) (By similarity). Interacts with SLC6A4. Interacts with STK33. Interacts with LARP6. Interacts with RAB8B (By similarity).

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines.

Post-translational modifications:
Filament disassembly during mitosis is promoted by phosphorylation at Ser-55 as well as by nestin. One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized. Phosphorylation by PKN1 inhibits the formation of filaments. Phosphorylated at Ser-56 by CDK5 during neutrophil secretion in the cytoplasm. Phosphorylated by STK33.

Similarity:
Belongs to the intermediate filament family.

Gene ID:
7431

Database links:

Entrez Gene: 7431 Human

Entrez Gene: 22352 Mouse

Entrez Gene: 81818 Rat

Omim: 193060 Human

SwissProt: P08670 Human

SwissProt: P20152 Mouse

SwissProt: P31000 Rat

Unigene: 455493 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

波形蛋白抗体 

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hz-0701R GCS/glucosylceramide synthase  谷氨酸半胱氨酸γ合成酶抗体

hz-5971R Plzf  早幼粒细胞白血病锌指蛋白抗体

hz-1023R CSF3/G-CSF  粒细胞-巨噬细胞集落刺激因子3抗体

hz-5116R GDIA1  肿瘤转移抑制基因GDIA1抗体

hz-5126R GDIA2/ARHGDIB  肿瘤转移抑制基因GDIA2抗体

hz-2574R G-CSFR/CD114  粒细胞-巨噬细胞集落刺激因子3受体抗体

hz-2356R GKRP  葡萄糖激酶调节蛋白抗体

hz-1794R GDF-1  生长、分化因子1抗体

hz-5099R GDF3  生长分化因子3抗体

hz-1288R GDF8/MSTN  生长分化因子8抗体

hz-2227G GDF8  生长分化因子8/肌肉抑制素抗体

hz-1795R GDF9  生长分化因子9抗体

hz-3818R GDF15/MIC-1  生长分化因子15/巨嗜细胞抑制因子1抗体

hz-1024R GDNF  胶质细胞源性神经营养因子抗体

hz-5972R Ribonuclease 6  核糖核酸酶6抗体

hz-5973R SIRT7  沉默调节样蛋白SirT7抗体

hz-1160R Gelsolin  凝溶胶蛋白抗体

hz-4292R BPI  杀菌/通透性增强蛋白抗体

hz-0199R GFAP  胶质纤维酸性蛋白抗体

hz-5355R phospho-GFAP (Ser8)  磷酸化胶质纤维酸性蛋白抗体

hz-6193R SMYD2  组蛋白甲基转移酶SMYD2抗体

hz-5974R SMYD3  组蛋白甲基转移酶SMYD3抗体

hz-6108R SMYD4  组蛋白甲基转移酶SMYD4抗体

hz-5975R SSX8  滑膜肉瘤X断点蛋白8抗体

hz-0639R GFP  绿色荧光蛋白（免疫组化用抗体）

hz-0844R GFP  绿色荧光蛋白抗体

hz-0890R GFP  绿色荧光蛋白抗体

hz-2194R EGFP  重组增强型绿色荧光蛋白抗体

hz-5977R c-Maf  原癌基因cMAF抗体

hz-5976R c-Maf  原癌基因cMAF抗体

hz-5978R c-Myb  转录激活因子MYB抗体

hz-0168R GFRA4  GDNF家族受体α-4抗体

hz-0201R GFR Alpha-1  GDNF家族受体α-1抗体