磺酰脲类药物受体1抗体

英文名称    SUR1    

中文名称    磺酰脲类药物受体1抗体    

别    名    ABC36; Abcc8; ATP binding cassette sub family C (CFTR/MRP) member 8; ATP binding cassette transporter sub family C member 8 (1); HHF1; HRINS; MRP8; PHHI; Sulfonylurea receptor 1; SUR.    

磺酰脲类药物受体1抗体        

说 明 书    0.1ml  0.2ml      

研究领域    免疫学  细胞膜受体  药物及化合物  糖尿病  内分泌病      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Horse, Guinea Pig,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    175kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human SUR1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磺酰脲类药物受体1抗体产品介绍    background:
SUR1 is a member of ATP binding cassette super family. SUR receptor confers the sensitivity of Kir6.2 to ATP/ADP sensitivity and to pharmacological agents such as sulfonylurea and diazoxide that close or open the KATP channels. The persistent heyperinsulinimic hypoglycemia in infancy (PHHI) is familial disorder due to defect in negative feed back in response to low glucose levels. SUR1 was mapped on chromosome 11p14-15.1, the same location where the gene for PHHI is located. It has been shown that the expression of Kir6.2 and SUR1 are regulated by glucose levels and the actives of glucogon like peptide receptor 1. Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene.

Subunit:
Interacts with KCNJ11.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Similarity:
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Contains 2 ABC transmembrane type-1 domains.
Contains 2 ABC transporter domains.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

磺酰脲类药物受体1抗体

hz-5070R HMGCS2  三羟基三甲基辅酶A合成酶2抗体

hz-1405R HNF1/TCF1/HNF1A  肝细胞核因子1α抗体

hz-3828R HNF4/TCF4/HNF4A  肝细胞核因子4α抗体

hz-4001R phospho-HNF4 (Ser313)  磷酸化肝细胞核因子4α抗体

hz-0827R HO-1  血红素氧合酶 1/热休克蛋白32抗体

hz-2075R Hhze Oxygenase 1/HO-1  血红素氧合酶 1/热休克蛋白32抗体

hz-1238R HO-2  血红素氧合酶2抗体

hz-3650R HOXB4  HOXB4抗体

hz-0394R HOXc8  HOXc8抗体

hz-2561R PSGD/HOXB13  同源盒蛋白HOXB13抗体

hz-1541R Heparanase  乙酰肝素酶抗体

hz-0928R phospho-HP1 alpha (Tyr24)  磷酸化异染色质蛋白1抗体（果蝇）

hz-2502R HOXA10  HOXA10抗体

hz-0930R Phospho-HP1(Tyr43)  异染色质蛋白1磷酸化抗体（果蝇）

hz-4046R HPCL2  植烷酰辅酶A羟化酶2抗体

hz-2902R HPL/PL  人胎盘泌乳素抗体

hz-2448R Nuclear Matrix Protein p84/NMP84   核基质p84蛋白抗体

hz-0990R HPV16-E6  人类乳头状瘤病毒16抗体

hz-0991R HPV18 E6  人类乳头状瘤病毒18 E6抗体

hzm-0991M HPV18 E6 monoclonal  人类乳头状瘤病毒18 E6单克隆抗体

hz-1719R HPV16 E6 + HPV18 E6  人类乳头状瘤病毒16/18 E6抗体

hz-0992R HPV16-E7  人类乳头状瘤病毒16-E7抗体

hz-2212R rHPV  重组人乳头瘤病毒抗体

hz-4623R HPV16-E7  人类乳头状瘤病毒16-E7抗体

hz-1808R Hpt/Haptoglobin  结合珠蛋白/触珠蛋白抗体

hz-1071R HRAS/Ras/Ras p21  原癌基因H-ras抗体

hz-6165R HRAS+KRAS  转化蛋白p21抗体（原癌基因H-ras抗体）

hz-1814R HRG-alpha/Neuregulin 1  Heregulin α蛋白抗体

hz-0945R albumin/AFM  人血清白蛋白抗体

hzm-0945M Albumin(3F4)  人血清白蛋白单克隆抗体

hz-1817R HRG Beta1  Heregulin β蛋白抗体