24脱氢胆固醇还原酶抗体

英文名称    Seladin 1    

中文名称    24脱氢胆固醇还原酶抗体    

别    名    Seladin1; Seladin-1; DHCR24; 24 dehydrocholesterol reductase; 3-beta-hydroxysterol delta-24-reductase; DCE; Desmosterol to cholesterol enzyme; Diminuto dwarf1 homolog; SELADIN1; Selective AD indicator 1; Selective Alzheimer's Disease Indicator 1.    

24脱氢胆固醇还原酶抗体          

说 明 书    0.2ml      

研究领域    肿瘤  免疫学  神经生物学  信号转导  细胞凋亡  转录调节因子  Alzheimer's      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    55/110kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Seladin 1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

24脱氢胆固醇还原酶抗体   产品介绍    background:
Seladin 1 is highly expressed in brain, adrenal tissues and adrenal tumours, where this enzyme catalyzes the reduction of the delta-24 double bond of sterol intermediates such as desmosterol, during cholesterol biosynthesis. In addition, Seladin 1 has an anti-apoptotic function by reducing caspase 3 activity during oxidative stress-induced apoptosis and protecting cells against amyloid-beta peptide-induced apoptosis. Several studies have identified a reduction in expression levels of this enzyme in brain regions affected by Alzheimer's disease (hippocampus and the subventricular zone). 

Subunit:
Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.

Tissue Specificity:
Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex.

Similarity:
Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
Contains 1 FAD-binding PCMH-type domain.

Database links:

Entrez Gene: 1718 Human

Entrez Gene: 74754 Mouse

Entrez Gene: 298298 Rat

Omim: 606418 Human

SwissProt: Q15392 Human

SwissProt: Q8VCH6 Mouse

SwissProt: Q5BQE6 Rat

Unigene: 498727 Human

Unigene: 133370 Mouse

Unigene: 225146 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

24脱氢胆固醇还原酶抗体   

hz-6299R PRUNE/DRES17  乳腺癌相关蛋白DRES17抗体

hz-6300R Thz7R/Plxdc2  肿瘤血管内皮标记相关蛋白质7抗体

hz-5156R phospho-LSP1 (Ser252)  磷酸化白细胞F肌动蛋白结合蛋白抗体

hz-6301R MAP3K2/MEKK2  丝裂原活化蛋白激酶激酶2抗体

hz-6304R IFNA4/IFNA76/IFNA M1  干扰素α4抗体

hz-6305R Ryanodine Receptor  心肌兰尼碱受体抗体（脑肌兰尼碱受体）

hz-6306R GCMA/GCM1  绒毛膜特异性转录因子GCMa抗体

hz-6307R Desmocollin 1  桥粒糖蛋白1抗体

hz-6308R UACA  葡萄膜自身抗原Uaca抗体

hz-6309R IL-6  白介素6抗体

hz-6310R Caveolin-2  细胞质膜微囊蛋白-2抗体

hzm-1621M AFP(A2)  甲胎蛋白单克隆抗体（包被）

hzm-1622M AFP(A4)  甲胎蛋白单克隆抗体(检测)

hz-6311R BSCL2/SPG17  先天性脂肪代谢障碍蛋白2抗体（常染色体显性遗传痉挛性截瘫17）

hz-6312R IL-6  白介素6抗体

hz-6313R 4 Hydroxynonenal  4羟基壬烯酸抗体

hz-6314R NANOS2  生殖细胞增殖相关蛋白NANOS2抗体

hz-6315R CTBP2  C末端结合蛋白2抗体

hz-6316R PTGER1  前列腺素EP1受体抗体

hz-6317R phospho-PLB/phospholamban(phospho Ser16+Thr17)  磷酸化心脏磷蛋白抗体

hz-6318R ASM/Acid sphingomyelinase  酸性神经鞘磷脂酶抗体

hz-6319R IL-1 Beta/IL-1B  白介素1β抗体

hz-6320R BFAR/RNF47  环指蛋白47抗体

hz-6321R WISP1  Wnt1信号通路蛋白1抗体

hz-6322R Annexin A8  膜粘连蛋白8抗体

hz-6323R CD105/Endoglin  CD105抗体

hz-6325R GLUT10/Glucose Transporter GLUT10  葡萄糖转运蛋白10抗体

hz-6326R CD54/ICAM-1  细胞间粘附分子1抗体

hz-6327R Filaggrin  兜甲蛋白抗体

hz-6329R Sortilin/NTR3/Gp95  神经降压素受体3抗体（糖蛋白95）

hz-6330R IFNA16/Interferon alpha 16  干扰素α16抗体

hz-6331R NET1  去甲肾上腺素转运蛋白/神经递质去甲肾上腺素转运体抗体

hz-6332R ABCA2  三磷酸腺苷结合盒转运蛋白2抗体

hz-6333R ApoB/Apolipoprotein B  载脂蛋白B抗体

hz-6334R ORP8  氧化固醇结合蛋白8抗体

hz-6335R ALOX15B/15 Lipoxygenase 2  花生四烯酸15脂氧合酶2抗体

hz-6336R APOB48R  载脂蛋白B受体抗体