磷酸化信号转导和转录激活因子5b抗体

英文名称    phospho-STAT5b(Ser731)    

中文名称    磷酸化信号转导和转录激活因子5b抗体    

别    名    STAT5b(phospho S731); Transcription factor STAT5B; Signal transducer and activator of transcription 5B; STA5B_HUMAN; STAT5; Stat5b.    

磷酸化信号转导和转录激活因子5b抗体        

说 明 书    0.1ml      

产品类型    磷酸化抗体     

研究领域    肿瘤  细胞生物  免疫学  染色质和核信号  信号转导  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    90kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated Synthesised phosphopeptide derived from human STAT5b around the phosphorylation site of Ser731    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷酸化信号转导和转录激活因子5b抗体产品介绍    background:
Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.

Function:
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription.

Subunit:
Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1, NMI and SOCS7. Interacts (via SH2 domain) with INSR.

Subcellular Location:
Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocated into the nucleus in response to phosphorylation (By similarity).

Post-translational modifications:
Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2. Phosphoryation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity.

DISEASE:
Growth hormone insensitivity with immunodeficiency (GHII) [MIM:245590]: A disease characterized by short stature, growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, resistance to hexogeneous growth hormone therapy, and recurrent infections. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the transcription factor STAT family. 
Contains 1 SH2 domain. 

Database links:
UniProtKB/Swiss-Prot: P51692.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

磷酸化信号转导和转录激活因子5b抗体

hz-3064R Phospho-ATP1A1(Ser23)  磷酸化钠钾ATP酶蛋白a1抗体

hz-2732R ATXN1/Ataxin-1  脊髓小脑失调症蛋白1抗体

hz-3037R phospho-ATP citrate lyase(Ser455)  磷酸化三磷酸腺柠檬酸裂解酶抗体

hz-3929R ATP citrate lyase/ACLY  三磷酸腺柠檬酸裂解酶抗体

hz-3008R phospho-ATXN1(Ser775)  磷酸化失调症蛋白1抗体

hz-2438R AVEN  细胞死亡调节蛋白抗体(凋亡、半胱胺酸蛋白酶激活抑制剂)

hz-5213R phospho-ATXN1(Thr236)  磷酸化失调症蛋白1抗体

hz-2436R Kir6.2  ATP敏感性钾通道亚基kir6.2抗体

hz-4214R GIRK2/Kir3.2  G蛋白激活内流钾通道蛋白2抗体

hz-1705R AVPR2  精氨酸加压素受体2抗体

hz-2422R Bdkrb2/B2R  缓激肽B2受体抗体

hz-2439R Axin1  轴蛋白1抗体

hz-2437R Anei-ATX/Autotaxin  自分泌运动因子抗体

hz-2749R Aurora A/ARK-1/AURKA  有丝分裂激酶A抗体

hz-2445R Aurora B/STK-1  有丝分裂激酶B抗体

hz-5179R phospho-PTPRA(Tyr798)  磷酸化酪氨酸磷酸酶α抗体

hz-5175R phospho-PTPRA(Ser180)  磷酸化酪氨酸磷酸酶α抗体

hz-2750R Aurora C  有丝分裂激酶B抗体

hz-2751R Aurora A/B/C  有丝分裂激酶A/B/C抗体

hz-4118R LEO1  RNA聚合酶相关蛋白LEO1抗体

hz-1103R B7-H1/PD-L1/CD274  程序性死亡配体1抗体

hz-1868R B7-DC/CD273/PDL2  程序性死亡配体2抗体

hz-2471R ICOS-L/B7-H2/CD275  诱导协同刺激分子配体CD275抗体

hz-5410R phospho-LEO1(Ser551)  磷酸化RNA聚合酶相关蛋白LEO1抗体

hz-4661R ICOS-L/B7-H2/CD275  诱导协同刺激分子配体CD275抗体

hz-4164R CT054/C20orf54  核黄素转运蛋白2抗体

hz-4229R ZDHHC21  γ-氨基丁酸A受体相关膜蛋白3

hz-4119R ASGPR1/ASGR1  唾液酸糖蛋白受体1抗体

hz-4242R ITPR1  5-三磷酸肌醇受体1抗体

hz-4126R GPI  糖磷脂酰肌醇抗体

hz-0673R B7H4  B7-H4抗体

hz-4243R ITPR2  5-三磷酸肌醇受体2抗体

hz-5040R BAAT  长链脂肪酸酰基辅酶A水解酶抗体