粘结蛋白SA2抗体

英文名称    SA2    

中文名称    粘结蛋白SA2抗体    

别    名    Cohesin Subunit SA 2; Cohesin subunit SA-2; DKFZp686P168; DKFZp781H1753; SA 2; SA2; SCC3 homolog 2; STAG 2; STAG 2; stag2; STAG2_HUMAN; Stromal antigen 2; FLJ25871; bA517O1.1.    

粘结蛋白SA2抗体         

说 明 书    0.2ml      

研究领域    细胞生物  细胞周期蛋白  细胞分化  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    141kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human SA2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

粘结蛋白SA2抗体 产品介绍    background:
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.

Function:
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.

Subunit:
Interacts directly with RAD21 in cohesin complex. Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG2 is mutually exclusive with STAG1 and STAG3. 

Subcellular Location:
Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. 

Post-translational modifications:
Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity). 

Similarity:
Belongs to the SCC3 family. 
Contains 1 SCD (stromalin conservative) domain. 

Database links:
UniProtKB/Swiss-Prot: Q8N3U4.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

粘结蛋白SA2抗体 

hz-6859R Caspase 14  半胱胺酸蛋白酶蛋白14抗体

hz-6860R Caspase 5  半胱胺酸蛋白酶蛋白5抗体

hz-6861R Fhz1A  前列腺素E受体4相关蛋白抗体

hz-6862R LANPL  富含亮氨酸样酸性核蛋白抗体

hz-6863R MALT1  粘膜相关淋巴组织淋巴瘤转运蛋白1抗体

hz-6864R NALP12  NALP12抗体

hz-6865R NALP6  富含亮氨酸重复结构域蛋白6抗体

hz-6866R NLRP7  富含亮氨酸重复结构域蛋白7抗体

hz-6867R NLRP9  富含亮氨酸重复结构域蛋白9抗体

hz-6868R ARMER  ARMER抗体

hz-6869R HBXIP  乙型肝炎病毒X蛋白相互作用蛋白

hz-6870R ILP2  抑制细胞凋亡样蛋白2抗体

hz-6871R Interferon alpha 6  干扰素α6抗体

hz-6872R Rffl/RING finger protein 189  环指蛋白189抗体

hz-6873R CERKL  视网膜色素变性蛋白26抗体

hz-6874R Catalase  过氧化氢酶抗体

hz-6875R Adenylate kinase 2/AK2  腺苷酸激酶1抗体

hz-6876R FMRP/FMR1  脆性X智力低下蛋白抗体

hz-6877R IFRD1  干扰素相关发育调节蛋白1抗体（神经生长因子诱导蛋白PC4）

hz-6878R PERP/p53 apoptosis effector related to PMP22  p53凋亡相关作用蛋白PMP22抗体

hz-6879R phospho-GATA-4(ser 262)  磷酸化GATA结合蛋白4抗体

hz-6880R GPR109A/Puma gamma  G蛋白偶联受体109A抗体

hz-6881R SCN3B  电压门控钠通道SCN3B蛋白抗体

hz-6882R TIS11D/ERF2  表皮生长因子反应蛋白2抗体

hz-6883R xCT/CCBR1  钙离子通道阻端耐药蛋白CCBR1抗体

hz-6884R TSSC3  肿瘤抑制转移候选基因3抗体

hz-6885R TTI1  转录因子相互作用蛋白1抗体

hz-6886R WDR61  WD重复膜蛋白61抗体

hz-6887R RBR2/Rb2 p130  视网膜母细胞瘤样蛋白2抗体

hz-6888R BRCC3/BRCC36  乳腺癌易感基因复合物亚基蛋白3抗体

hz-6889R Casein Kappa/CSN3/COPS3  K-酪蛋白抗体

hz-6890R CXXC5  二硫键氧化还原酶锌指蛋白5抗体

hz-6891R DMTF1  周期素D相互作用蛋白1抗体

hz-6892R GMCL1L  生殖细胞样蛋白1样蛋白抗体

hz-6893R KLLN   Killin-p53调节复制抑制蛋白抗体