亚砷盐相关蛋白抗体

英文名称    Spindly    

中文名称    亚砷盐相关蛋白抗体    

别    名    Rrhabdomyosarcoma antigen protein MU RMS 40.4A; Arsenite related gene 1 protein; Arsenite-related gene 1 protein; CCDC 99; Ccdc99; Coiled coil domain containing 99; Coiled-coil domain-containing protein 99; hSpindly; Protein Spindly; rhabdomyosarcoma antigen MU RMS 40.4A; Rhabdomyosarcoma antigen MU-RMS-40.4A; SPDLY_HUMAN; Spindly.    

亚砷盐相关蛋白抗体          

说 明 书    0.2ml      

研究领域    细胞生物  免疫学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    67kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Protein Spindly    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

亚砷盐相关蛋白抗体  产品介绍    background:
The five integral families of plant hormones consists of auxins, cytokinins, giberellins (GAs), abscisic acid (ABA), and ethylene. Giberellins, which consist of over fifty family members, mediate shoot growth. In Arabidopsis, SPINDLY (SPY) negatively regulates GA signal transduction. ERA1 (enhanced response to absisic acid), which is identical to WIGGUM, controls floral and shoot apical meristem size and floral organ number in response to ABA. Ethylene is perceived by a family of five receptors, one of which is ETR1, whereas CTR1 is a negative regulator of the ethylene signal transduction pathway . Ethylene is also produced endogenously in Arabidopsis via a biosynthetic pathway, which is catalyzed by ACC synthase and ACC oxidase.

Function:
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.

Subcellular Location:
Cytoplasm, cytoskeleton, centrosome. Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the Spindly family.

Gene ID:
54908

Database links:

Entrez Gene: 54908 Human

SwissProt: Q96EA4 Human

Unigene: 368710 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

亚砷盐相关蛋白抗体  

hz-2909R MARCKS  丙氨酸蛋白激酶C底物Marcks抗体

hz-3263R Phospho-MARCKS (Ser152/156)  磷酸化丙氨酸蛋白激酶C底物Marcks抗体

hz-3359R Phospho-MARCKS (Ser162)  磷酸化丙氨酸蛋白激酶C底物Marcks抗体

hz-5500R Phospho-MARCKS(Ser170)  磷酸化丙氨酸蛋白激酶C底物Marcks抗体

hz-1595R MAD1  Mad1抗体

hz-0642R MAdCAM-1  粘膜血管定居因子抗体

hz-3859R MAGP2  纤微丝相关糖蛋白2抗体

hz-1975R DAXX  死亡相关蛋白6抗体(Fas死亡区相关蛋白)

hz-3135R Phospho-FADD(Ser191)  磷酸化Fas相关死亡结构域蛋白抗体

hz-5288R phospho-DAXX (Ser213)  磷酸化Fas相关死亡结构域蛋白抗体

hz-5291R phospho-DAXX (Ser495)  磷酸化Fas相关死亡结构域蛋白抗体

hz-5292R phospho-DAXX (Ser517)  磷酸化Fas相关死亡结构域蛋白抗体

hz-5293R phospho-DAXX (Ser671)  磷酸化Fas相关死亡结构域蛋白抗体

hz-0924R Mafa  v-maf 肌腱膜纤维肉瘤癌基因同源物A抗体

hz-2591R MAFbx/Fbx32  泛素蛋白连接酶抗体

hz-0257R MAG-a/b  髓鞘相关糖蛋白a/b抗体

hz-0258R MAG-a/L-MAG  髓鞘相关糖蛋白-a抗体

hz-0817R MAGE-1  黑色素瘤相关抗原抗体

hz-3645R MAGE-A4  黑色素瘤相关抗原4抗体

hz-3802R Mammaglobin A  乳腺珠蛋白1抗体

hz-3803R Mammaglobin B  乳腺珠蛋白2抗体

hz-2931R Mammaglobin A  乳腺珠蛋白1抗体

hzm-2028M Marijuana(2B1)  小鼠抗大麻单克隆抗体

hz-4053R MAVS  线粒体抗病毒信号MAVS蛋白抗体

hz-2340R 14-3-3E/YWHAE  14-3-3E蛋白抗体

hz-2076R Methamphetamine  甲基苯丙胺抗体

hzm-2068M Methamphetamine(4D2)  甲基苯丙胺单克隆抗体

hz-5141R MATR3/Matrin 3  核基质蛋白3抗体

hz-3636R MO25 alpha/CAB39  钙结合蛋白39抗体

hz-4054R Methionine adenosyltransferase  蛋氨酸腺苷转移酶抗体

hz-5590R phospho-YWHAE(Thr232)  磷酸化14-3-3E蛋白抗体

hz-2884R Mesothelioma  间质细胞蛋白抗体

hz-5084R ME1  胞浆苹果酸酶1抗体

hz-5424R MAP3K7IP3  NFKB激活蛋白1抗体

hz-3588R TORC1/CRTC1  环腺苷酸应答元件结合蛋白转录共激活因子TORC1抗体

hz-3453R Phospho-Torc1/Crtc1 (Ser151)  磷酸化CREB转录共激活因子TORC1抗体

hz-3591R MAP3K8/TPL2  丝裂原活化蛋白激酶激酶8抗体