线性泛素链相关蛋白SHARPIN抗体

英文名称    SHARPIN    

中文名称    线性泛素链相关蛋白SHARPIN抗体    

别    名    hSIPL1; Shank associated RH domain interacting protein; SHANK associated RH domain interactor; Shank interacting protein like 1; Shank-associated RH domain-interacting protein; Shank-interacting protein-like 1; Sharpin; SHRPN_HUMAN; SIPL1; DKFZp434N1923.    

线性泛素链相关蛋白SHARPIN抗体         

说 明 书    0.2ml      

研究领域    肿瘤  细胞生物  泛素      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    40kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human SHARPIN    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

线性泛素链相关蛋白SHARPIN抗体  产品介绍    background:
SHARPIN is a 387 amino acid protein that localizes to the cytoplasm and contains one RanBP2-type zinc finger. Expressed at high levels in placenta and skeletal muscle and present at lower levels in colon, brain, heart, liver, kidney, lung, thymus and small intestine, SHARPIN interacts with Shank 1 and is thought to play a role in the control of inflammatory responses and in the overall development of the immune system. SHARPIN exists as three alternatively spliced isoforms and shares 73% sequence identity with its mouse counterpart, suggesting a conserved role between species. The gene encoding SHARPIN maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.

Function:
May have a role in normal immune development and control of inflammation.

Subunit:
Monomer and homodimer. Interacts with SHANK1, EYA1 and EYA2 (By similarity). Component of the LUBAC complex (linear ubiquitin chain assembly complex) which consists of SHARPIN, RBCK1 and RNF31. LUBAC has a MW of approximative 600 kDa suggesting a heteromultimeric assembly of its subunits. Associates with the TNF-R1 signaling complex (TNF-RSC) in a stimulation-dependent manner.

Subcellular Location:
Cytoplasm. Enriched at synaptic sites in mature neurons where it colocalizes with SHANK1.

Tissue Specificity:
Highly expressed in skeletal muscle and placenta and at lower levels in brain, heart, colon without mucosa, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes.

Similarity:
Contains 1 RanBP2-type zinc finger.

Database links:

Entrez Gene: 81858 Human

Omim: 611885 Human

SwissProt: Q9H0F6 Human

Unigene: 529755 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

线性泛素链相关蛋白SHARPIN抗体  

hz-0590R Cytoglobin  细胞球蛋白抗体

hz-2756R CYLD  微管结合蛋白CYLD抗体

hz-3080R phospho-CYLD(Ser418)  磷酸化微管结合蛋白CYLD抗体

hz-1606R CYP1A1  细胞色素P450 1A1抗体

hz-2589R P450 1A2/CYP1A2  细胞色素P450 1A2抗体

hz-3608R CYP11A1/P450SCC  细胞色素P450 11A1抗体

hz-2887R CYP2C9  细胞色素P450 2C9抗体

hz-3898R CYP11B1  细胞色素P450 11B1抗体

hz-4108R Cytochrome P450 2D1  细胞色素CYP2D1抗体

hz-1742R CYP3A4  细胞色素P450 3A4抗体

hz-2375R CYP3A1  细胞色素P450 3A1抗体

hz-5054R CYP4A1  细胞色素P450 4A1抗体

hz-4019R CYP5A1/Thromboxane synthase  血栓素合成酶抗体

hz-5055R CYP4A22  细胞色素P4504A22抗体（脂肪酸Ω羟化酶）

hz-2399R CYP7A1  细胞色素P450 7A1抗体/胆固醇7a羟化酶

hz-2991R CYP2D6  细胞色素P450 2D6抗体

hz-2352R Cytochrome P450 2B6  细胞色素P450 2B6抗体

hz-3853R CYP17  细胞色素P450 17抗体

hz-1292R CYP19/CYP19A1  细胞色素P450 19抗体

hz-5052R CYP7B1  胆固醇25α7羟化酶抗体

hz-3677R CYP8A1/PTGIS  前列环素合成酶抗体

hz-2443R CYP21  胆固醇21-羟化酶抗体

hz-2795R CYP2C19  细胞色素P450 2C19抗体

hz-3899R CYP24A1  细胞色素P450 24A1抗体

hz-5049R CYP27A1  胆固醇27α羟化酶抗体

hz-0461R CYP450  细胞色素P450单氧化酶抗体

hz-5816R RRAGA  RAS相关GTP结合蛋白A抗体

hz-1290R Cyr61/IGFBP10/CCN1  富半胱氨酸肝素结合蛋白61抗体

hz-1725R CYP2E1  细胞色素P450ⅡE1抗体

hz-4562R CYP2E1  细胞色素P450ⅡE1抗体

hz-3900R CYP2R1  细胞色素P450 2R1抗体