钠通道亚基β4抗体

英文名称    SCN4B    

中文名称    钠通道亚基β4抗体    

别    名    SCN4B_HUMAN. Sodium channel subunit beta-4.    

钠通道亚基β4抗体      

说 明 书    0.1ml  0.2ml      

研究领域    心血管  神经生物学  信号转导  通道蛋白      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    22kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human SCN4B (81-162aa)    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

钠通道亚基β4抗体产品介绍    background:
The SCN4B protein modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation By similarity. The protein has been found to be expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10) [MIM:611819]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy. 

Function:
Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation.

Subunit:
The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds. Associates with SCN2A

Subcellular Location:
Membrane; Single-pass type I membrane protein

Tissue Specificity:
Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart.

Post-translational modifications:
Contains a number of interchain disulfide bonds with SCN2A 

DISEASE:
Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10) [MIM:611819]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy.

Similarity:
Belongs to the sodium channel auxiliary subunit SCN4B (TC 8.A.17) family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Database links:
UniProtKB/Swiss-Prot: Q8IWT1.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

钠通道亚基β4抗体

hz-4297R CLIP1/CLIP170  细胞质连接蛋白1抗体

hz-3483R Phospho-CDK2 (Thr160)  磷酸化周期素依赖性激酶2抗体

hz-5277R Phospho-CDK2 (Thr14)  磷酸化周期素依赖性激酶2抗体

hz-1680R CDK3  周期素依赖性激酶3抗体

hz-0633R CDK4  周期素依赖性激酶4抗体

hz-4299R CNTROB  乳腺癌易感基因2相互作用蛋白抗体

hz-5727R HEC1  癌细胞高表达蛋白Hec1抗体

hz-0559R CDK5  周期素依赖性激酶5抗体

hz-5728R HURP/DAP5  肝癌上调蛋白抗体

hz-0568R CDK6  周期素依赖性激酶6抗体

hz-5286R phospho-CDK6 (Tyr13)  磷酸化周期素依赖性激酶6抗体

hz-5287R phospho-CDK6 (Tyr24)  磷酸化周期素依赖性激酶6抗体

hz-0569R CDK7  周期素依赖性激酶7抗体

hz-5729R LGALS3BP  可溶性半乳糖凝集素3结合蛋白抗体

hz-5248R phospho-CDK7 (Thr170)  磷酸化周期素依赖性激酶7抗体

hz-5730R MAD2  有丝分裂阻滞缺陷蛋白2抗体

hz-0570R CDK8  周期素依赖性激酶8抗体

hz-1388R CDK9/Cyclin T1  周期素依赖性激酶9抗体

hz-3097R Phospho-CDK9 (Thr186)  磷酸化周期素依赖性激酶9抗体

hz-5249R Phospho-CDK9 (Thr29)  磷酸化周期素依赖性激酶9抗体

hz-2361R CDK10  周期素依赖性激酶10

hz-3999R CDK11  周期素依赖性激酶11抗体

hz-0538R CDKN1C/p57 Kip2  周期蛋白依赖激酶抑制因子1C抗体

hz-5731R Mad2L1  有丝分裂阻滞缺陷2样蛋白1抗体

hz-3713R Phospho-p57 Kip2 (Thr310)  磷酸化周期蛋白依赖激酶抑制因子1C抗体

hz-5732R NEK2  中心体相关蛋白激酶Nek2抗体

hz-1093R CGP-39/YKL-40  软骨糖蛋白39抗体

hz-0060R CEA/CD66e/CEACAM5  癌胚抗原抗体

hz-5733R PAR6  缺陷性分配同源物α抗体

hz-0719R CEA  癌胚抗原抗体

hzm-1623M CEA(C3)  癌胚抗原单克隆抗体（包被）

hzm-1624M CEA(B5)  癌胚抗原单克隆抗体（检测）

hz-5734R PCGF1  表观抑制因子Polycomb家族成员PCGFl蛋白抗体