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嗜热菌杀酵母素
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Product Name: Myriocin from Mycelia sterilia
| 别名: | 多球壳菌素 |
| CAS号: | 35891-70-4 |
| 分子式: | C21H39NO6 |
| 分子量: | 401.54 |
| MDL号: | MFCD01632772 |
嗜热菌杀酵母素
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| 介绍: | Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis. Myriocin suppresses replication of the hepatitis C virus (HCV) in a murine model. |
| 特定比重: | 1.123 |
| 贮存: | 储存温度:2-8 ℃. |
| 生化和生理学机理: | Fungal metabolite with potent immunosuppressant activity. Inhibits serine palmitoyltransferase at picomolar concentrations blocking synthesis of ceramide, a precursor of sphingomyelin and glycosphingolipids. Disrupts substratum adhesion of melanoma cells. It has been suggested that its immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction. |
嗜热菌杀酵母素
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上海沪震实业有限公司
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310112001371133
成立日期
2012-05-08
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100
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