Novus NFKB信号通路产品

核因子-KB（Nuclear factor-kappa B, NF-KB）蛋白家族是一种多效的转录因子，可以与多种启动子部位的KB位点发生特异性结合，从而促使其转 录表达。其受氧化应激、细菌脂多糖、细胞因子等多种刺激而活化后，调控前炎症性细胞因子、细胞表面受体、转录因子、粘附分子等生成。

NNFkB主要存在于细胞质中，并与抑制性的IkB蛋白形成复合物，当IkB磷酸化之后，NFkB被释放，并转位到细胞核。NFkB在凋亡和细胞存活上有着矛 盾的功能，NFkB通过抑制p53依赖的凋亡和上调Bcl-2家族的抗凋亡成员和caspase抑制剂（如XIAP和FLIP），介导了许多信号的存活反应。相反，NFkB也被DNA损伤中的凋亡刺激所激活，介导了促凋亡基 因（如TRAIL R2/DR5、Fas和Fas配体）的上调。

目录号 名称 种属反应性 应用 NBP1-62000 c-Rel Antibody Hu WB, ELISA, IHC-P NB100-92032 FADD Antibody Hu, Ms WB, IHC-P NB100-91824 IKK alpha Antibody Hu, Mu, Rt WB, IHC-P NB100-56509 KK beta Hu, Ms ,WB FACS, IHC-P, IP NBP1-84681 IKK gamma Hu WB, ICC/IF, IHC-P NB100-2184 IL1 alpha Hu WB, ELISA NB600-633 IL1 beta Hu, Ca, Mk WB, ELISA, IHC, IP NB110-85471 IL1 Receptor Ms WB, IHC-P NBP1-61700 IRAK Hu WB, ELISA, ICC/IF, IHC-P NBP1-19785 MyD88 Hu, Mu, Rt WB, IHC-P NBP1-77395 NFkB p105/p50 Hu, Ms, WB, ICC/IF, IHC-P NBP1-96139 NFkB p65 Hu, Ms, Mk WB, ICC/IF, IHC-P NB600-201 pan PKC Hu, Mu, Rt WB, ELISA, ICC/IF, IHC-Fr, IHC-P, IP, RIA NBP1-45883 TCR-alpha Hu, Mu, Rt WB, IHC-Fr, IHC-P, IP NBP1-33357 TRAF6 Hu WB NB110-57461 RelB Hu WB, ICC/IF, IHC-P, IP

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