Rabbit Anti-SPRN

Rabbit Anti-SPRN antibody
Catalog Number :RS-2149R
Quantity size : 0.1ml (dilute with pH 7.4 0.01 M PBS or antibody diluent )
Background:
Prion diseases, or transmissible spongiform encephalopathies (TSEs), are manifested as genetic,
infectious or sporadic lethal neurodegenerative disorders involving alterations of the prion protein
(PrP). Constitutively expressed in normal adult brain, cellular PrP (PrP(C)) is sensitive to
proteinase K digestion and is converted to the disease form, PrPSc, through alterations in protein
folding conformation, which make it resistant proteases. SPRN (shadow of prion protein), also
known as SHO or SHADOO, is a 151 amino acid cytoplasmic protein that is mainly expressed in
brain. SPRN is considered a prion-like protein that has PrP(C)-like neuroprotective activity and
may act as a modulator for the biological actions of normal and abnormal PrP. In humans,
mutations in the gene encoding SPRN may be associated with variant and sporadic
Creutzfeldt-Jakob disease, a degenerative neurological disorder that is incurable and invariably
fatal.
朊病毒蛋白（朊蛋白相关蛋白、沙杜蛋白）是导致动物脑细胞死亡的传染性病毒蛋白，是一种致病性神经
蛋白。朊蛋白相关蛋白Shadoo 是近期才被发行的新朊蛋白，其传播、传染过程尚不清楚，发病机理还有待
于研究中。
Specificity : Anti-SPRN is a rabbit monoclonal antibody
specific for anti-SPRN of cow
-use for western blotting,elisa,immunoprecipitation and immunohistochemistry
-Protein G affinity chromatography purification, purity :>95%
-Isotype: IgG
-mol wt: 12 kDa
Application :
WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-
500 lmmunohistochem1：100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user..
Storage: Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized
antibody is stable at room temperature for at least one month and for greater than a year when
kept at -20 ℃ . When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the
antibody is stable for at least six weeks at 2-4 ℃
Important Note: This product as supplied is intended for research use only, not for use in
human, therapeutic or diagnostic applications.Rabbit Anti-SPRN