兔抗LINGO1多克隆抗体
中文名称: 兔抗LINGO1多克隆抗体
英文名称: Anti-LINGO1 rabbit polyclonal antibody
别 名: LERN1; LRRN6A; UNQ201
相关类别: 一抗
储 存: 冷冻(-20℃)
宿 主: Rabbit
抗 原: LINGO1
反应种属: Human, Mouse
标 记 物: Unconjugate
克隆类型: rabbit polyclonal
技术规格: 兔抗LINGO1多克隆抗体
Background: | Lingo-1 is a 614-amino acid protein that plays an important role in the negative regulation of myelination by oligodendrocytes in the central nervous system (CNS). Lingo-1 is a nervous system-specific transmembrane protein that interacts with NgR1 and p75 to make up a receptor complex that binds to Nogo, a protein that inhibits axonal regeneration. Reduction of Lingo-1 activity downregulates RhoA (a protein related to cytoskeleton regulation) activity, promotes oligodendrocyte differentiation, and increases axonal myelination in neuronal tissues. Conversely, overexpression of Lingo-1 activates RhoA and inhibits oligodendrocyte differentiation and myelination. Lingo-1 up-regulation may be a characteristic of activity-induced neural plasticity responses. Lingo-1 may be a critical deterrent of myelin and nerve fiber repair in multiple sclerosis, an inflammatory disease that causes gradual destruction of myelin in the CNS. |
Applications: | ELISA, IHC |
Name of antibody: | LINGO1 |
Immunogen: | Synthetic peptide of human LINGO1 |
Full name: | leucine rich repeat and Ig domain containing 1 |
Synonyms: | LERN1; LRRN6A; UNQ201 |
SwissProt: | Q96FE5 |
ELISA Recommended dilution: | 5000-10000 |
IHC positive control: | Human cervical cancer |
IHC Recommend dilution: | 10-50 |
企业名称
上海酶联生物科技有限公司
企业信息已认证
企业类型
有限责任公司(自然人投资或控股)
信用代码
91310112594715010G
成立日期
2012-04-18
注册资本
人民币500.0000万元整
经营范围
从事生物科技专业技术领域内的技术咨询、技术服务、技术开发、技术转让,化工产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品)、纺织原料、洗涤用品、一类医疗器械的销售。(依法须经批准的项目,经相关部门批准后方可开展经营活动1
上海酶联生物科技有限公司
公司地址
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