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当前位置: 顺元生物 > 蛋白质/多肽 > Recombinant Mouse BH3 Interacting Domain Death Agonist p15

Recombinant Mouse BH3 Interacting Domain Death Agonist p15

供货周期: 7天
品牌:
型号: 2μg
货号: PRO-644
报价: ¥700
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产品介绍
Synonyms Truncated BH3-interacting domain death agonist, p22 BID, BID, FP497, MGC15319, MGC42355, tBID.
Introduction Truncated BH3 interacting domain death agonist is a truncated form of the pro-apoptotic full-length BID. Truncated BH3 interacting domain death agonist is generated by Caspase-8 cleavage of BID. The truncated form of the protein translocates from the cytosol to mitochondria and transduces apoptotic signals.
BID is a pro-apoptotic Bcl-2 protein having only the BH3 domain. In reaction to apoptotic signaling, BID interacts with another Bcl-2 family of cell death regulators, called Bax, they form a heterodimer resulting to the insertion of Bax into the outer mitochondrial membrane. Bax induces the opening of the mitochondrial voltage-dependent anion channel which lead to the release of cytochrome c and other pro-apoptotic factors from the mitochondria resulting in activation of caspases. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8). CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. The major proteolytic product p15 BID releasea cytochrome c. Isoform 1, Isoform 2 and Isoform 4 induce ice-like proteases and apoptosis while Isoform 3 does not induce apoptosis.
Description Truncated BID Mouse Recombinant also called BH3-interacting domain death agonist p15 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 61-195 amino acids (135 a.a.) and having a molecular mass of 15.4 kDa.
Source Escherichia Coli.
Physical Appearance Sterile Filtered colorless liquid formulation.
Formulation The Mouse Truncated BID protein solution contains 10mM Tris-HCl pH-8, 1mM EDTA and 250mM NaCl.
Stability Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity Greater than 95.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Usage ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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上海顺元生物科技有限公司

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310116002748169

成立日期

2012-11-29

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50

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Recombinant Mouse BH3 Interacting Domain Death Agonist p15由上海顺元生物科技有限公司为您提供,货号PRO-644,规格:2μg,CAS号:,如您想了解更多关于Recombinant Mouse BH3 Interacting Domain Death Agonist p15价格、Recombinant Mouse BH3 Interacting Domain Death Agonist p15结构式、批发、用途等信息,欢迎咨询。除供应Recombinant Mouse BH3 Interacting Domain Death Agonist p15外,还可为您提供Mouse Methylthioadenosine Phosphorylase(MTAP)ELISA kit、人转化生长因子β1(TGFB1)抗体ELISA kit、猴弹性蛋白酶2,中性粒细胞(ELA2)ELISA kit等试剂,公司有专业的客户服务团队,是您值得信赖的合作伙伴,顺元生物客户服务电话,售前、售后均可联系。
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