Chemical Name1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione
Biological Activity
Description
Aloe-emodin
Targets
IC50
In vitro
Aloe-emodin is an interferon-inducing agent with IC50 of about 1 ug/mL for JEV and of about 0.33 ug/mL for EV71. It is an anthraquinone present in aloe latex, an exudate from the aloe plant. It was identified as a potential interferon (IFN)-inducer by screening compounds from Chinese herbal medicine. Aloe-emodin showed low cytotoxicity to human HL-CZ promonocyte cells and TE-671 medulloblastoma cells and significantly activated interferon-stimulated response element (ISRE) and gamma-activated sequence (GAS)-driven cis-reporting systems.