URB597|5mg|K1390-上海高创化学科技有限公司

SKU:K1390		M. Wt:338.4
Formula:C20H22N2O3		Solubility:No
Purity:>99%		Storage:2 years at -20 degrees centigrade
CAS No.:546141-08-6		Synonyms:KDS-4103
Chemical NameN/A

Description	URB597
In vitro	URB597 is a highly selective O-arylcarbamate inhibitor of intracellular FAAH activity.
In vivo	Administration of the selective FAAH inhibitor URB597 (cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester; 0.3 mg/kg i.p.) increases anandamide levels in the brain of rats and wild-type mice but has no such effect in FAAH-null mutants. URB597 enhances the hypothermic actions of anandamide (5 mg/kg i.p.) in wild-type mice but not in FAAH-null mice. URB597 does not alter the hypophagic response elicited by OEA (5 and 10 mg/kg i.p.), which is mediated by activation of peroxisome proliferator-activated receptor type-alpha.

Description

URB597

In vitro

URB597 is a highly selective O-arylcarbamate inhibitor of intracellular FAAH activity.

In vivo

Administration of the selective FAAH inhibitor URB597 (cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester; 0.3 mg/kg i.p.) increases anandamide levels in the brain of rats and wild-type mice but has no such effect in FAAH-null mutants. URB597 enhances the hypothermic actions of anandamide (5 mg/kg i.p.) in wild-type mice but not in FAAH-null mice. URB597 does not alter the hypophagic response elicited by OEA (5 and 10 mg/kg i.p.), which is mediated by activation of peroxisome proliferator-activated receptor type-alpha.

工商信息

企业名称

上海高创化学科技有限公司

企业信息已认证

企业类型

信用代码

310228001353263

成立日期

2010-06-05

注册资本

经营范围

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