GSK1070916|2mg|K1370-上海高创化学科技有限公司

SKU:K1370		M. Wt:507.63
Formula:C30H33N7O		Solubility:No
Purity:>99%		Storage:2 years at -20 degrees centigrade
CAS No.:942918-07-2		Synonyms:N/A
Chemical NameN/A

Description	GSK1070916
Targets	Aurora B	Aurora C
IC50	3.5 nM	6.5 nM
In vitro	GSK1070916 can inhibit Aurora B and Aurora C with IC50 of 3.5 nM and 6.5 nM. Human tumor cells treated with GSK1070916 shows dose-dependent inhibition of phosphorylation on serine 10 of Histone H3, a substrate specific for Aurora B. Moreover, GSK1070916 inhibits the proliferation of tumor cells with EC50 values of <10 nM in over 100 cell lines spanning a broad range of tumor types, with a median EC50 of 8 nM.
In vivo	GSK1070916 (25, 50, or 100 mg/kg) shows dose-dependent inhibition of phosphorylation of an Aurora B specific substrate in mice and consistent with its broad cellular activity, has antitumor effects in 10 human tumor xenograft models including breast, colon, lung, and two leukemia models. [2]
Clinical Trials	N/A
Features	N/A

Description

GSK1070916

Targets

Aurora B

Aurora C

IC50

3.5 nM

6.5 nM

In vitro

GSK1070916 can inhibit Aurora B and Aurora C with IC50 of 3.5 nM and 6.5 nM. Human tumor cells treated with GSK1070916 shows dose-dependent inhibition of phosphorylation on serine 10 of Histone H3, a substrate specific for Aurora B. Moreover, GSK1070916 inhibits the proliferation of tumor cells with EC50 values of <10 nM in over 100 cell lines spanning a broad range of tumor types, with a median EC50 of 8 nM.

In vivo

GSK1070916 (25, 50, or 100 mg/kg) shows dose-dependent inhibition of phosphorylation of an Aurora B specific substrate in mice and consistent with its broad cellular activity, has antitumor effects in 10 human tumor xenograft models including breast, colon, lung, and two leukemia models. [2]

Clinical Trials

N/A

Features

N/A

工商信息

企业名称

上海高创化学科技有限公司

企业信息已认证

企业类型

信用代码

310228001353263

成立日期

2010-06-05

注册资本

经营范围

从事化学科技、计算机领域内技术开发、技术咨询、技术服务,从事生物科技领域内技术开发、技术咨询,化学试剂、化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备(除医疗器械),仪器仪表,Ⅰ类医疗器械,金属制品,电子产品,机电产品销售。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

GSK1070916由上海高创化学科技有限公司为您提供，货号K1370，规格：2mg，CAS号：942918-07-2，如您想了解更多关于GSK1070916价格、GSK1070916结构式、批发、用途等信息，欢迎咨询。除供应GSK1070916外，还可为您提供大鼠酸性磷酸酶(ACP)ELISA Kit、重组人半乳糖凝集素16/LGALS16 Human、兔子基质金属蛋白酶抑制因子1(TIMP-1)ELISA Kit等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海高创客户服务电话，售前、售后均可联系。