GSK256066|2mg|K1367-上海高创化学科技有限公司

SKU:K1367		M. Wt:518.58
Formula:C27H26N4O5S		Solubility:No
Purity:>99%		Storage:2 years at -20 degrees centigrade
CAS No.:801312-28-7		Synonyms:N/A
Chemical NameN/A

Description	GSK256066
Targets	PDE4B
IC50	3.2 pM
In vitro	GSK256066 is a slow and tight binding inhibitor of PDE4B with apparent IC50 of 3.2 pM. GSK256066 is an extremely potent inhibitor of LPS-stimulated TNFalpha production in PBMCs with pIC50 of 11.0 and IC50 of 10 pM and human whole-blood cultures with pIC50 of 9.90 and IC50 of 126 pM.
In vivo	GSK256066 inhibits the LPS-induced pulmonary neutrophilia with ED50 of 2.9 ug/kg, achieving maximal inhibition of 62% when given in the dry powder formulation. GSK256066 shows a moderate plasma clearance of 39 ml/min/kg, a moderate volume of distribution of 0.8 L/kg, and a relatively short half-life of 1.1 hour in the male CD rat.
Clinical Trials	N/A
Features	N/A

Description

GSK256066

Targets

PDE4B

IC50

3.2 pM

In vitro

GSK256066 is a slow and tight binding inhibitor of PDE4B with apparent IC50 of 3.2 pM. GSK256066 is an extremely potent inhibitor of LPS-stimulated TNFalpha production in PBMCs with pIC50 of 11.0 and IC50 of 10 pM and human whole-blood cultures with pIC50 of 9.90 and IC50 of 126 pM.

In vivo

GSK256066 inhibits the LPS-induced pulmonary neutrophilia with ED50 of 2.9 ug/kg, achieving maximal inhibition of 62% when given in the dry powder formulation. GSK256066 shows a moderate plasma clearance of 39 ml/min/kg, a moderate volume of distribution of 0.8 L/kg, and a relatively short half-life of 1.1 hour in the male CD rat.

Clinical Trials

N/A

Features

N/A

工商信息

企业名称

上海高创化学科技有限公司

企业信息已认证

企业类型

信用代码

310228001353263

成立日期

2010-06-05

注册资本

经营范围

从事化学科技、计算机领域内技术开发、技术咨询、技术服务,从事生物科技领域内技术开发、技术咨询,化学试剂、化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备(除医疗器械),仪器仪表,Ⅰ类医疗器械,金属制品,电子产品,机电产品销售。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

GSK256066由上海高创化学科技有限公司为您提供，货号K1367，规格：2mg，CAS号：801312-28-7，如您想了解更多关于GSK256066价格、GSK256066结构式、批发、用途等信息，欢迎咨询。除供应GSK256066外，还可为您提供Gibco山羊血清（新西兰）、兔子血清、重组人半乳糖凝集素8/Human LGALS8 His等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海高创客户服务电话，售前、售后均可联系。