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重组人p53 蛋白/p53 Human
产品编号：PRO-742
产品规格：2μg/5μg/10μg
产品规格：2μg/5μg/10μg
| Catalogue Number | PRO-742 |
| Synonyms | Cellular tumor antigen p53, Tumor suppressor p53, Phosphoprotein p53, Antigen NY-CO-13, TP53, P53, LFS1, TRP53, FLJ92943. |
| Introduction |
Tumor protein p53 responds to various cellular stresses by regulating target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. p53 is a DNA-binding protein containing transcription activation, DNA-binding & oligomerization domains. p53 binds to mdm2, SV40 T antigen and human papilloma virus E6 protein p53 senses DNA damage and possibly facilitating repair. p53 protein is a transcription factor which is encoded in humans by the TP53 gene. alterations of TP53 occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. p53 mutants that often occur in many different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma. The p53 expression in normal cells is low and in an assortment of transformed cell lines is high, which may contribute to transformation and malignancy. Multiple p53 variants encode distinct isoforms, which can regulate p53 transcriptional activity. p53’s significance in multicellular organisms is in cell cycle regulation therefore it functions as a tumor suppressor that is involved in preventing cancer. p53’s role in conserving stability by preventing genome mutation has earned it descriptions such as "the guardian of the genome," "the guardian angel gene," and the "master watchman." The name p53 refers to its evident molecular mass: it migrates as a 53kDa protein on SDS-PAGE. However, based on calculations from its amino acid residues, p53's mass is in fact only 43.7kDa. This difference is attributed to the high number of proline residues in the protein which slow its migration on SDS-PAGE, consequently making it appear larger than it actually is. |
| Description | p53 Human Recombinant full length produced in E.Coli is a non-glycosylated, polypeptide chain having a total Mw of 81kDa. p53 Human Recombinant is fused to GST tag and purified by proprietary chromatographic techniques. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered clear solution. |
| Formulation | Purified human p53 in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% glycerol. |
| Stability |
For long term storage store at -20°C. Avoid freeze/thaw cycles. |
| Usage | Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
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厦门慧嘉生物科技有限公司
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成立日期
2009-06-05
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重组人p53 蛋白/p53 Human由厦门慧嘉生物科技有限公司为您提供，货号PRO-742，规格：2μg/5μg/10μg，CAS号：，如您想了解更多关于重组人p53 蛋白/p53 Human价格、重组人p53 蛋白/p53 Human结构式、批发、用途等信息，欢迎咨询。除供应重组人p53 蛋白/p53 Human外，还可为您提供人糖化血红蛋白A1c(GHbA1c)ELISA试剂盒Human GHbA1c ELISA试剂盒、人胎盘生长因子(PLGF)ELISA试剂盒Human PLGF ELISA试剂盒、人羧化不全骨钙素(ucOC)ELISA试剂盒Human ucOC ELISA试剂盒等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，厦门慧嘉科技客户服务电话，售前、售后均可联系。
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