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重组大鼠巨噬细胞炎症蛋白-1α/MIP 1a Rat
产品编号：CHM-343
产品规格：5μg/20μg/1mg
产品规格：5μg/20μg/1mg
| Catalogue Number | CHM-343 |
| Synonyms | Small inducible cytokine A3, CCL3, Macrophage inflammatory protein 1-alpha, MIP-1-alpha, Tonsillar lymphocyte LD78 alpha protein, G0/G1 switch regulatory protein 19-1, G0S19-1 protein, SIS-beta, PAT 464.1, chemokine (C-C motif) ligand 3, MIP1A, SCYA3, G0S19-1, LD78ALPHA. |
| Introduction | Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major forms, MIP-1a and MIP-1b that are now officially named CCL3 and CCL4 respectively. Both are major factors produced by macrophages after they are stimulated with bacterial endotoxins. They activate human granulocytes (neutrophils, eosinophils and basophils) which can lead to acute neutrophilic inflammation. They also induce the synthesis and release of other pro-inflammatory cytokines such as interleukin 1 (IL-1), IL-6 and TNF-a from fibroblasts and macrophages. The genes for CCL3 and CCL4 are both located on human chromosome 17. |
| Description |
Macrophage Inflammatory Protein-1 alpha Rat Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 69 amino acids and having a molecular mass of 7853 Dalton. The MIP-1a is purified by proprietary chromatographic techniques. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation | The protein was lyophilized from 1 mg/ml solution containing no additives. |
| Solubility | It is recommended to reconstitute the lyophilized Macrophage Inflammatory Protein-1a in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. |
| Stability |
Lyophilized MIP-1a although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL3 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Purity |
Greater than 97.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
| Amino acid sequence | The sequence of the first five N-terminal amino acids was determined and was found to be, Ala-Pro-Tyr-Gly-Ala. |
| Biological Activity | The Activity is calculated by the ability to chemoattract of rat peritoneal macrophages using a conc. of 60 ng/ml corresponding to a Specific Activity of 16,667IU/mg. |
| Protein content |
Protein quantitation was carried out by two independent methods 1. UV spectroscopy at 280 nm using the absorbency value of 1.38 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). 2. Analysis by RP-HPLC, using a calibrated solution of MIP-1a as a Reference Standard. |
| Usage | Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
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重组大鼠巨噬细胞炎症蛋白-1α/MIP 1a Rat由厦门慧嘉生物科技有限公司为您提供，货号CHM-343，规格：5μg/20μg/1mg，CAS号：，如您想了解更多关于重组大鼠巨噬细胞炎症蛋白-1α/MIP 1a Rat价格、重组大鼠巨噬细胞炎症蛋白-1α/MIP 1a Rat结构式、批发、用途等信息，欢迎咨询。除供应重组大鼠巨噬细胞炎症蛋白-1α/MIP 1a Rat外，还可为您提供人碳酸酐酶12(CA-12)ELISA试剂盒Human CA-12 ELISA试剂盒、人胎盘碱性磷酸酶(PLAP)ELISA试剂盒Human PLAP ELISA试剂盒、人髓磷脂碱性蛋白(MBP)ELISA试剂盒Human MBP ELISA试剂盒等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，厦门慧嘉科技客户服务电话，售前、售后均可联系。
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