Recombinant Human CD147

CD147 Human
CD147 Human Recombinant
Catalog No. PRO-494

Synonyms:
Basigin, Leukocyte activation antigen M6, Collagenase stimulatory factor, Extracellular matrix metalloproteinase inducer, EMMPRIN, 5F7, Tumor cell-derived collagenase stimulatory factor, TCSF, OK blood group antigen, CD147 antigen, BSG, M6, OK, CD147.

Introduction:
EMMPRIN (extracellular matrix metalloproteinase inducer) also called CD147 is a 58 kDa protein with two immunoglobulin domains that was originally purified from the plasma membrane of the human LX-1 lung carcinoma cell line. EMMPRIN has been localized on the outer surface of tumor cells, where it interacts with fibroblasts to stimulate the expression of matrix metalloproteinases (MMPs). EMMPRIN expression has been observed in normal oral mucosa epithelium, kidney tissue, neoplastic oral squamous cell carcinoma, lung carcinoma, urinary bladder cancer, in situ ductal breast carcinoma and in the peripheral granulocytes of rheumatoid arthritis patients. High level of EMMPRIN expression has been shown to correlate with both MMP expression and cancer invasive potential.

Description:
CD147 Human Recombinant full length protein expressed in E.coli, shows a 84 kDa band on SDS-PAGE.
The CD147 is purified by proprietary chromatographic techniques.

Source:
Escherichia Coli.

Physical Appearance:
Sterile Filtered clear solution.

Formulation:
CD147 at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.

Stability:
Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles.

Applications:
• ELISA
• Inhibition Assays
• Western Blotting

Usage:
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.