APC Human
Activated Protein C Human Recombinant
Catalog No. ENZ-349
Synonyms:
Coagulation factor V, Activated protein C cofactor, FVL, PCCF, factor V, APC.
Introduction:
Activated Protein C exerts an antithrombotic effect by inhibiting Factors Va and VIIIa.
In vitro data indicate that Activated Protein C has indirect profibrinolytic activity through its ability to inhibit plasminogen activator inhibitor-1 (PAI-1) and limiting generation of activated thrombin-activatable-fibrinolysis-inhibitor. Additionally, in vitro data indicate that Activated Protein C may exert an anti-inflammatory effect by inhibiting human tumor necrosis factor production by monocytes, by blocking leukocyte adhesion to selectins, and by limiting the thrombin-induced inflammatory responses within the microvascular endothelium.
Description:
Activated Protein C Human Recombinant produced in CHO is a disulfide-linked homodimeric, glycosylated, polypeptide chain having a molecular mass of 55kDa.
Activated Protein C Human Recombinant is a serine protease with the same amino acid sequence and glycosilation sites as the human plasma-derived Activated Protein C.
The APC is purified by proprietary chromatographic techniques.
Source:
Chinese Hamster Ovary Cells (CHO).
Physical Appearance:
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:
Each mg protein contains 7. 6mg sodium chloride, 1.5 mg citrate and 6 mg sucrose.
Solubility:
It is recommended to reconstitute the lyophilized Coagulation factor V in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
Stability:
Lyophilized Factor V although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution APC should be stored at 4°C between 2-7 days and for future use below
-18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
Purity:
Greater than 99.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE..
Usage:
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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企业名称
上海希美化学有限公司
企业信息已认证
企业类型
信用代码
310228001203103
成立日期
2009-05-31
注册资本
10
经营范围
化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备,仪器仪表,金属制品,电子产品,机电产品销售,从事化工科技、计算机科技领域内技术开发、技术咨询、技术服务。【依法须经批准的项目,经相关部门批准后方可开展经营活动】
上海希美化学有限公司
公司地址
上海市松江区陆家圈路168弄113号
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