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当前位置: 上海希美化学 > 蛋白质/多肽 > 人α血红蛋白稳定蛋白(AHSP)

人α血红蛋白稳定蛋白(AHSP)

供货周期: 一周
品牌:
规格: 10µg
货号: PRO-720
CAS号:
报价: ¥800
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产品介绍
Synonyms Alpha-hemoglobin-stabilizing protein, Erythroid-associated factor, Erythroid differentiation-related factor, AHSP, EDRF, ERAF.
Introduction Alpha-hemoglobin stabilizing protein (AHSP) is an erythroid-specific protein that acts as a chaperone to prevent the aggregation of ?-hemoglobin during normal erythroid cell development. AHSP specifically protects free ?-hemoglobin from precipitation in live cells and in solution. AHSP is expected to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia. Furthermore, AHSP promotes alpha globin chain stability in human erythropoiesis. In addition, the AHSP stabilizes the alpha-Hb chain, thus avoiding its precipitation and its ability to generate ROS, which is implicated in cell death. AHSP is expressed in blood and bone marrow. AHSP subunit is a monomer, it forms a heterodimer with free alpha-hemoglobin. On the other hand, AHSP does not bind beta-hemoglobin nor alpha2beta2 hemoglobin A. AHSP is downregulated in TSEs (transmissible spongiform encephalopathies).
Description AHSP Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 102 amino acids (1-102 a.a.) and having a molecular mass of 11.8kDa.
The AHSP is purified by proprietary chromatographic techniques.
Source Escherichia Coli.
Physical Appearance Sterile Filtered colorless solution.
Formulation The AHSP protein solution contains 20mM Tris-HCl buffer (pH8.0) and 10% glycerol.
Stability AHSP although stable 4°C for 4 weeks, should be stored desiccated below -18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
Amino Acid Sequence MALLKANKDL ISAGLKEFSV LLNQQVFNDP LVSEEDMVTV VEDWMNFYIN YYRQQVTGEP QERDKALQEL RQELNTLANP FLAKYRDFLK SHELPSHPPP SS.
Purity Greater than 95.0% as determined by SDS-PAGE.
Usage ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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企业名称

上海希美化学有限公司

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信用代码

310228001203103

成立日期

2009-05-31

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10

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人α血红蛋白稳定蛋白(AHSP)由上海希美化学有限公司为您提供,货号PRO-720,规格:10µg,CAS号:,如您想了解更多关于人α血红蛋白稳定蛋白(AHSP)价格、人α血红蛋白稳定蛋白(AHSP)结构式、批发、用途等信息,欢迎咨询。除供应人α血红蛋白稳定蛋白(AHSP)外,还可为您提供人体血红蛋白A1c(Human Hemoglobin A1c/HbA1c)、兔糖化血红蛋白A1c(GHbA1c)ELISA Kit、大鼠糖化血红蛋白A1c(GHbA1c)ELISA Kit等试剂,公司有专业的客户服务团队,是您值得信赖的合作伙伴,上海希美化学客户服务电话,售前、售后均可联系。
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