APP Phospho(pT743)antibody
Cat.#: 3926-1
Rabbit Monoclonal Antibody
Clone ID: EPR826(2)
Swiss Prot: P05067
Mol Weight: 100 - 120kDa
Size: 100ul
Description
Alzheimer's disease (AD) is characterized by the presence of senile plaques in the brain and blood vessel walls. Amyloid Beta A4 (Aβ4) protein has been found to be the principal constituent of senile plaques of ADs patients (1-2). APP is proteolytically cleaved to generate the 4 kDa Aβ4 protein. Two variants of Aβ4 can be detected; Aβ1-40 short-tailed and Aβ1-42 long-tailed (3-4).
Recommended Applications
WB, IP
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IP: 1:10 - 100
Species Reactivity
Human, Mouse, Rat
Species cross-reactivity is based on WB analysis
Products Data
Western blot analysis on human brain lysates using anti-Phospho-APP (pT743) RabMAb (cat. #3926-1). Cells were either (A) untreated (B) treated with Lambda Phosphatase.
Specificity
A phospho specific peptide corresponding to residues surrounding Threonine 743 of human APP was used as an immunogen. This antibody only detects APP phosphorylated at Threonine 743.
Storage Condition and Buffer
Store at -20° C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Alternative Names
APP antibody, AAA antibody, ABETA antibody, ABPP antibody, AD1 antibody, APPI antibody, CTFgamma antibody, CVAP antibody, PN2 antibody, C31 antibody, Gamma-CTF(50) antibody
Description References
1. Glenner, G. G., Wong, C. W. (1984) Biochem. Biophys. Res. Commun. 120, 885-890
2. Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B., Beyreuther, K. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 4245-4249
3. Dovey, H. F., Suomesaari-Chrysler, S., Lieberburg, I., Sinha, S., and Kiem, P. S. (1993) NeuroReport 4, 1039-1042
4. Vigo-Pelfrey, C., Lee, D., Keim, P., Lieberburg, I., Schenk, D. B. (1993) J. Neurochem. 61, 1965-1968
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企业名称
上海希美化学有限公司
企业信息已认证
企业类型
信用代码
310228001203103
成立日期
2009-05-31
注册资本
10
经营范围
化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备,仪器仪表,金属制品,电子产品,机电产品销售,从事化工科技、计算机科技领域内技术开发、技术咨询、技术服务。【依法须经批准的项目,经相关部门批准后方可开展经营活动】
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公司地址
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