APP antibody
Cat.#: 1565-1
Rabbit Monoclonal Antibody
Clone ID: Y188
Swiss Prot: P05067
Mol Weight: 95kDa
Size: 100ul
Description
Alzheimer's disease (AD) is characterized by the presence of senile plaques in the brain and blood vessel walls. Amyloid Beta A4 (Aβ4) protein has been found to be the principal constituent of senile plaques of ADs patients (1-2). APP is proteolytically cleaved to generate the 4 kDa Aβ4 protein. Two variants of Aβ4 can be detected; Aβ1-40 short-tailed and Aβ1-42 long-tailed (3-4).
Recommended Applications
WB, IHC, ICC, IP, FC
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IHC: 1:250-500
ICC: 1:250-500
IP: 1:50
FC: 1:20
Species Reactivity
Human, Mouse, Rat
For Mouse, this antibody is recommended for WB only
Rat cross reactivity tested by western blot only
Products Data
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Staining of various paraffin-embedded human tissue samples using anti-APP RabMAb (cat#1565-1). Human brain tissue showed positive immunohistochemical staining for Amyloid Beta A4 precursor. Tissues were stained in parallel on the same Normal Tissue Array.
Staining of various paraffin-embedded human tissue samples using anti-APP RabMAb (cat#1565-1). Human breast showed negative staining. Tissues were stained in parallel on the same Normal Tissue Array.
Specificity
A synthetic peptide corresponding to residues in the NPXY motif of human APP was used as immunogen. This antibody specifically recognizes APP and its isoforms. It will not recognize either of the two Amyloid Beta Protein ( Aβ4 ) variants, Aβ1 -40 or Aβ1 -42.
Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Alternative Names
APP antibody, AAA antibody, ABETA antibody, ABPP antibody, AD1 antibody, APPI antibody, CTFgamma antibody, CVAP antibody, PN2 antibody, C31 antibody, Gamma-CTF(50) antibody
Description References
1. Glenner, G. G., Wong, C. W. (1984) Biochem. Biophys. Res. Commun. 120, 885-890
2. Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B., Beyreuther, K. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 4245-4249
3. Dovey, H. F., Suomesaari-Chrysler, S., Lieberburg, I., Sinha, S., and Kiem, P. S. (1993) NeuroReport 4, 1039-1042
4. Vigo-Pelfrey, C., Lee, D., Keim, P., Lieberburg, I., Schenk, D. B. (1993) J. Neurochem. 61, 1965-1968
Product References
1. Barbagallo AP, Wang Z, Zheng H, et al, A Single Tyrosine Residue in the Amyloid Precursor Protein Intracellular Domain Is Essential for Developmental Function ,J Biol Chem 286 (2011) 8717-8721
2. Wang ZL, Wang BP, Yang L, et al, Presynaptic and Postsynaptic Interaction of the Amyloid Precursor Protein Promotes Peripheral and Central Synaptogenesis ,J. Neurosci. 29 (2009) 10788 - 10801
3. Li H, Wang B, Wang Z, et al, Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP ,Proc Natl Acad Sci U S A 107 (2010) 17362-17367
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企业名称
上海希美化学有限公司
企业信息已认证
企业类型
信用代码
310228001203103
成立日期
2009-05-31
注册资本
10
经营范围
化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备,仪器仪表,金属制品,电子产品,机电产品销售,从事化工科技、计算机科技领域内技术开发、技术咨询、技术服务。【依法须经批准的项目,经相关部门批准后方可开展经营活动】
上海希美化学有限公司
公司地址
上海市松江区陆家圈路168弄113号
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