High-throughput CD spectral measurement: biomedicines and pH dependency

2019-06-05 15:04

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资料摘要：

Biomedicine is a medicinal response to a physical or biological issue with the human body. Biomedicines use active ingredients derived from proteins and the research and development behind these methods is increasing daily. However, these biomedicines are more sensitive to environmental changes, such as a change in temperature, pH, and salt concentration, than traditional pharmaceuticals. To meet the demand for increased sample throughput in the modern pharmaceutical laboratory, JASCO has developed a fully automated high-throughput CD spectral measurement system. This system is composed of a J-1500 CD spectrometer with an autosampler unit. The high-throughput CD system enables the automation of sample pretreatment, injection and washing. In this application note, we will demonstrate the use of the ASU-800 automated system to evaluate the pH dependency on the structure of human serum albumin (HSA)

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