摘 要：纳米压印技术通过压印实现了纳米结构的图形转移，具有分辨率高、效率高、成本低的优点。通过对纳米压印过程中影响图形精度的一些因素进行分析，提出了相应的解决方法。结合研制的NiL-1型压印机进行工艺实验，给出纳米压印工艺实验的结果，并对结果进行了分析。 试验表明：考虑到影响压印图形精度的各种因素，采用镀有Cr的SiO2模版和NiL-1型压印机，用热压印技术可以压印出具有100nm特征尺寸的PMMA图形。

We describe biocompatible and nontoxic nanoparticles for in vivo tumor targeting and detection based on pegylated gold nanoparticles and surface-enhanced Raman scattering (SERS). Colloidal gold has been safely used to treat rheumatoid arthritis for 50 years, and has recently been found to amplify the efficiency of Raman scattering by 14–15 orders of magnitude. Here we show that large optical enhancements can be achieved under in vivo conditions for tumor detection in live animals. An important finding is that small-molecule Raman reporters such as organic dyes were not displaced but were stabilized by thiolmodified polyethylene glycols. These pegylated SERS nanoparticles were considerably brighter than semiconductor quantum dots with light emission in the near-infrared window. When conjugated to tumor-targeting ligands such as single-chain variable fragment (ScFv) antibodies, the conjugated nanoparticles were able to target tumor biomarkers such as epidermal growth factor receptors on human cancer cells and in xenograft tumor models.

美国DeltaNu公司最新Advantage 1064型台式拉曼光谱仪，采用1064nm波长作为激光光源，完全避免荧光干扰，方便用于凝胶、粉末、溶液、固体的测试。

美国DeltaNu公司Inspector便携式拉曼光谱 - 手提式，全球最小，便于户外使用 - 只重2.3Kg，电池可连续运行5小时 - 蓝牙技术，无限传输数据至计算机 - 配备专用Nuscope显微镜和三维载物台，立刻成为一台简易的显微拉曼光谱仪

摘要 光谱核型分析（SKY）可揭示G,R,Q带通常无法检测的染色体染色体结构上的细微变异，已经成为染色体核型分析的一种精确，灵敏，可靠的检测手段。

Combine DeltaNu’s portable Inspector ™ with Mesophotonic’s nanoscale photonic Klarite® crystals and you have a team ready for trace detection and surface science. In 1977 when Professor Richard Van Duyne at Northwestern University [1] and Martin Fleischman at Southampton University discovered anomalously large enhancements from electrochemical roughened surfaces the phrase nano had not become the craze that it is today. Now we know that the enhancements are due to nanoscale roughness on the surface. Amazingly these nanofeatures have led to tremendous advances in fundamental science and in applications requiring trace detection.

摘 要 介绍了近五年来应用拉曼光谱研究核酸及其组分、蛋白质及其组分和生组织等生物体系及其与其它物质相互作用的研究概况，展望了该技术在生物体系的应用前景。 关键词 Raman 光谱 核酸 蛋白质 生物组织