Pion PAMPA药物渗透性测试系统

PAMPA综合性论文——Astellas公司发表于Journal of Medicinal Chemistry

Effective permeability measured by parallel artificial membrane permeability assay (PAMPA) method. bpH of donor buffer. pION membrane lipid was used. cN.T.: not tested. dCytotoxicity was observed at high concentration conditions.

GIT PAMPA渗透性测试相关论文——发表于Journal of Medicinal Chemistry

Optimization of Chloronitrobenzamides (CNBs) as Therapeutic Leads for Human African Trypanosomiasis (HAT)

BBB PAMPA渗透性测试相关论文——发表于Journal of Medicinal Chemistry

Optimization of Novel Indole-2-carboxamide Inhibitors of Neurotropic Alphavirus Replication

PAMPA综合性论文——发表于2006年european journal of pharmaceutical sciences

PAMPA—A drug absorption in vitro model 13. Chemical selectivity due to membrane hydrogen bonding: In combo comparisons of HDM-, DOPC-, and DS-PAMPA models

GIT PAMPA渗透性测试相关论文——Boehringer Ingelheim制药集团发表于Journal of Medicinal Chemistry

Identification of a Potent Sodium Hydrogen Exchanger Isoform 1(NHE1) Inhibitor with a Suitable Profile for Chronic Dosing and Demonstrated Cardioprotective Effects in a Preclinical Model of Myocardial Infarction in the Rat

BBB PAMPA渗透性测试相关论文——耶鲁大学发表于Journal of Medocomal Chemistry

Substrate-Based Fragment Identification for the Development of Selective, Nonpeptidic Inhibitors of Striatal-Enriched Protein Tyrosine Phosphatase

PAMPA综合性论文——发表于2004年European Journal of Pharmaceutical Sciences

PAMPA—a drug absorption in vitro model 11. Matching the in vivo unstirred water layer thickness by individual-well stirring in microtitre plates

GIT PAMPA渗透性测试相关论文——发表于Journal of Medicinal Chemistry

Lead Optimization of Antimalarial Propafenone Analogues

BBB PAMPA渗透性测试相关论文——发表于Journal of Medicinal Chemistry

Novel Inhibitors of Neurotropic Alphavirus Replication That Improve Host Survival in a Mouse Model of Acute Viral Encephalitis

PAMPA综合性论文——发表于2004年的European Journal of Pharmaceutical Sciences

PAMPA—a drug absorption in vitro model 8. Apparent filter porosity and the unstirred water layer

GIT PAMPA渗透性测试相关论文——发表于2013年DRUG METABOLISM AND DISPOSITION

Significance of Reductive Metabolism in Human Intestine and Quantitative Prediction of Intestinal First-Pass Metabolism by Cytosolic Reductive Enzymes

BBB PAMPA相关论文——发表于2006年Wiley InterScience

numerous statements have been made about the utility of the PAMPA including its use as a screen for blood–brain barrier (BBB) permeability5 and also as a tool for medicinal chemists to elucidate structure–permeability relationships

PAMPA综合性论文——发表于2014年的《European Journal of Pharmaceutical Scie》

The PAMPA Explorer?, PAMPA Evolution? (pION INC) software packages were used for performing permeability measurements and data analysis. The 96-well STIRWELL? PAMPA sandwiches (P/N: 110243) and the stirring bars (P/N: 110211) were from pION INC. The UV plates were from Greiner Bio-one (UV-star micro plate, clear, flat bottom, half area). The manufacturer-calibrated pipettes (EDP-3 and pipet lite series) were purchased from Mettler-Toledo. The Gut-Box? from pION INC was used for stirring.